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Member Profile

Membership type: full

Najla Kharrat

Country of origin: Tunisia Currently in: Tunisia, Sfax General field of specialization: Other
Academic Background


2019 Other
Research and Profession

Current Research Activities


Cardiovascular diseases, protein cluster charge, genomics

Research Keywords: 
computational biology
cardiovascular diseases

Publications resulting from Research: 

Najla Kharrat, Ines Zidi, Rania abdelhedi, Amna Ben Hassine, Ahmed Baligh Laaribi, Hamza Ben Yahia, Nouha Abdelmouleh, Leila Abid, Ahmed Rebai, Roberta Rizzo Non classical human leukocyte antigen (HLA-G, HLA-E, and HLA-F) in coronary artery disease. (In press), Human immunology (2016).

Abdelhedi R, Bouayed NA, Alfadhli S, Abid L, Rebai A, Kharrat N. Characterization of drug-metabolizing enzymes CYP2C9, CYP2C19 polymorphisms in Tunisian, Kuwaiti and Bahraini populations. J Genet. 2015, 94(4):765-70.

Zidi I, Kharrat N, Sebai R, Zidi N, Yahia HB, Bouaziz A, Rifi H, Mezlini A, Rizzo R. Pregnancy and breastfeeding: a new theory for sHLA-G in breast cancer patients? Immunol Res. 2015

Ben Halim N, Dorboz I, Kefi R, Kharrat N, Eymard-Pierre E, Nagara M, Romdhane L, Ben Alaya-Bouafif N, Rebai A, Miladi N, Boespflug-Tanguy O, Abdelhak S. Determination of arylsulfatase A pseudodeficiency allele and haplotype frequency in the Tunisian population. Neurol Sci. 2015 ; 14.

Belmabrouk S, Kharrat N, Benmarzoug R, Rebai A. Exploring proteome-wide occurrence of clusters of charged residues in eukaryotes. Proteins. 2015; 11.

Louati R, Abdelmoula NB, Trabelsi I, Abid D, Lissewski C, Kharrat N, Kamoun S, Zenker M, Rebai T. Clinical and Molecular Findings of Tunisian Patients with RASopathies. Mol Syndromol. 2014 ; 5(5):212-7

Lasram K, Ben Halim N, Hsouna S, Kefi R, Arfa I, Ghazouani W, Jamoussi H,Benrahma H, Kharrat N, Rebai A, Ben Ammar S, Bahri S, Barakat A, Abid A, Abdelhak S. Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis. Biomed Res Int. 2014;2014:265274

Bougacha-Elleuch N, Charfi N, Kharrat N, Ayadi F, Maalej A, Chabchoub G, Rebai A, Kammoun-Krichen M, Belguith-Maalej S, Abid M, Mnif M, Ayadi H. A 20 year history of clinical and genetic study of thyroid autoimmunity in a Tunisian multigenerational family: Evidence for gene interaction. Meta Gene. 2013 ;29;2:63-71.

Fourati M, Mnif M, Kharrat N, Charfi N, Kammoun M, Fendri N, Sessi S, Abid M,Rebai A, Fakhfakh F.Association between Leptin gene polymorphisms and plasma leptin level in three consanguineous families with obesity. Gene. 2013; 7.S0378-1119(13)00731-2

Rania Abdelhedi, Najla Kharrat, Nouha Abdelmoula Bouayed ,Wafa Abdelmouleh, Imen Trabelsi Sahnoun , Suad AlFadhli, Leila Abid, Lobna Laroussi and Ahmed Rebai. Polymorphisms of the NOS3 and ACE gene in southern Tunisian samples with Coronary Artery Disease and controls. Biochem Genet. 2013 Feb;51(1-2):92-100.

Najla Kharrat, Wafa Abdelmouleh, Rania Abdelhedi, AlFadhli Suad, Ahmed Rebai.The Linkage disequilibrium pattern of the ACE gene in Arabic and Asian population groups. Annals of human Bioogy. 2012 Nov-Dec;39(6):538-40.

Fourati H, Bouzid D, Abida O, Kharrat N, Mnif F, Haddouk S, Fesel C, Costa J, Ben Ayed M, Abid M, Rebai A, Penha-Gonçalves C, Masmoudi H. Non-HLA autoimmunity genetic factors contributing to Autoimmune Polyglandular Syndrome type II in Tunisian patients. Hum Immunol. 2012 ;73(7):740-6.

Fourati H, Bouzid D, Abida O, Kharrat N, Marzouk S, Fesel C, Ben Ayed M, Bahloul Z, Penha-Gonçalves C, Rebai A, Masmoudi H. Genetic factors contributing to systemic Lupus erythematosus in Tunisian Patients. Journal clinical cellular immunology.2012 ; 3(4):3-129.

Triki –Fendri S, AlFadhli S, Ayadi I, Kharrat N, Ayadi H, Rebai A.Genetic Structure in Kuwaiti Population Revealed by Y-STR Diversity. Annals of Human Biology 2010, 37(6):827-35.

AlFadhli Suad, Kharrat Najla & Rebai Ahmed. Genome Scan Meta-Analysis in Systemic Lupus Erythematosus Strong linkage with loci 6p22.3-p21.1, and 2q31.1-34. Journal of Medical Genetics and Genomics. Journal of Medical Genetics and Genomics, 2010; Vol. 2 (1).

Choura M, Frikha F, Kharrat N, Aifa S, Rebaï A. Investigating the Function of Three Non-Synonymous SNPs in EGFR Gene: Structural Modelling and Association With Breast Cancer. Protein J. 2010; 29(1):50-4.

AlFadhli Suad, AlTimimy Bader, Kharrat Najla, AlSaeed Khalid, Haider Mohamad & Rebai Ahmed. Molecular analysis of HumDN1 VNTR polymorphism of the human deoxyribonuclease I in Systemic Lupus Erythematosus. Int J Immunogenet. 2010;37(1):5-8.
Kallel I, Kharrat N, Al-Fadhly S, Rebai M, Khabir A, Boudawara TS, Rebaï A. HER2 Polymorphisms and Breast Cancer in Tunisian Women. Genet Test Mol Biomarkers. 2009, 23.

Kharrat Najla, Suad Al’Fadhli and Ahmed Rebaï. Screening and validation of dinucleotide repeats in intron1 of human EGFR gene and its paralog in Her2 gene. Journal of Receptors and Signal Transduction. 2008; 28(5): 475-83.

Kharrat Najla, Suad Al’Fadhli, Maha. Rebaï, Mohamed. Sami Aifa, Imen. Kallel, Abdelmajid. Khabir, Tahia Sellami-Boudawara & Ahmed Rebaï. Dinucleotide (AC) repeat polymorphism in intron1 of human EGFR shows ethnic specificities and no evidence for association with breast cancer. Int J Biol Markers. 2007 ; 22(4):258-64.

Suad Al’fadhli, Kharrat Najla, Bader Al-Tememy, Arti Nanda and Ahmed Rebai. Susceptible and Protective Endothelial Nitric Oxide Synthase Gene Polymorphism in Alopecia Areata in the Kuwaiti population. Autoimmunity. 2008; 41(7):522-5.

Kharrat N, Maha Rebai & Ahmed Rebai. Linkage disequilibrium in the Human genome and its exploitation. Arcs. Inst. Pasteur Tunis, 2006.

Kharrat N, I. Ayadi & A. Rebai. 2006. Sample sizes computation for association studies using case-parents design. Journal of Genetics, 85(3):187-191.

M. Rebaï, Najla. Kharrat, I. Ayadi & A. Rebaï. Haplotype structure of five SNPs within the ACE gene in the Tunisian population. Annals of Human Bioloy, 33(3):319-329. 2006.

Current profession

Current professional activities type: 
coaching and montoring of new collegues newly recruted. Training and supervising students Build up of new collaboration and partnerships

Workshop and Conference Attended

2012 Istambul, turkey Bioinformatics Approaches for Analysis of High-throughput Biological Data
2015 Saoudi arabia International Genome Medecine Conference


active member in Association of the young Tunisian Researcher (ATCU)

Presentation given

Outils de modélisation graphique de réseaux géniques
Monastir, Tunisia
Event: 11ième journées d’immunologie
Bioinformatics in Tunisia
Event: Detection, gestion et analyse du polymorphisme des genomes végétaux
Prizes, Grants and Awards

TWAS Awards

Jun 2015
Research Grant agreement from TWAS