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Member Profile

Membership type: full

Youssra Al-Hilaly

Country of origin: Iraq Currently in: Iraq, Baghdad General field of specialization: Structural, Cell and Molecular Biology
Academic Background

Degrees

2014 Doctorate Structural, Cell and Molecular Biology
2003 Master Chemical Sciences
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

Research Keywords: 
Alzheimer's disease
protein misfolding
oxidative stress
amyloid
dityrosine
Tau protein
protein self assembly

Publications resulting from Research: 


Article
1. Youssra K. Al‐Hilaly; Bronwen E. Foster; Luca Biasetti; Liisa Lutter; Saskia J Pollack; Janet E. Rickard; John M.D. Storey; Charles R. Harrington; Wei‐Feng Xue; Claude M. Wischik; Louise C. Serpell (2019) Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain. FEBS Letters.

2. Al-Hilaly, Youssra K, Pollack, Saskia J, Rickard, Janet E, Simpson, Michael, Raulin, Ana-C, Baddeley, Thomas, Schellenberger, Pascale, Storey, John M D, Harrington, Charles R, Wischik, Claude M and Serpell, Louise C (2018) Cysteine-independent inhibition of alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT). Journal of Molecular Biology, 430 (21). pp. 4119-4131. ISSN 0022-2836

3. Al-Hilaly, Youssra K, Pollack, Saskia J, Vadukul, Devkee, Citossi, Francesca, Rickard, Janet E, Simpson, Michael, Storey, John M D, Harrington, Charles R, Wischik, Claude M and Serpell, Louise C (2017) Alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linking. Journal of Molecular Biology, 429 (4). pp. 3650-3665. ISSN 0022-2836

4. Al-Hilaly, Youssra K, Biasetti, Luca, Brakeman, Ben J, Pollack, Saskia J, Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R, Xue, Wei-Feng and Serpell, Louise C (2016) The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease. Scientific Reports, 6. p. 39171. ISSN 2045-2322

5. Marshall, Karen E, Vadukul, Devkee M, Dahal, Liza, Theisen, Alina, Fowler, Milena W, Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J, Staras, Kevin and Serpell, Louise (2016) A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration. Scientific Reports, 6. ISSN 2045-2322

6. Bukar Maina, Mahmoud, Al-Hilaly, Youssra and Serpell, Louise (2016) Nuclear tau and its potential role in Alzheimer’s disease. Biomolecules, 6 (1). 9 1-20. ISSN 2218-273X

7. Al-Hilaly, Youssra K, Williams, Thomas L, Stewart-Parker, Maris, Ford, Lenzie, Skaria, Eldhose, Cole, Michael, Bucher, William, Morris, Kyle L, Sada, Alaa, Thorpe, Julian R and Serpell, Louise C (2013) A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease. Acta Neuropathologica Communications, 1 (83). pp. 1-17. ISSN 2051-5960

8. Muslih, Raad K., Al-Kazzaz, Fatin F., Al-Hilaly Youssra K, (2012) Separation and Study Isoenzymes of Soluble Acetyl Cholinesterase in Nromal Human Brain and Gliomas Tumors. Al-Qadisiyah Journal of Pure Science, [S.l.], v. 17, n. 1, p. 112-120, ISSN 2411-35

Book Section
Vadukul, Devekee M, Al-Hilaly, Youssra K and Serpell, Louise C (2018) Methods for structural analysis of amyloid fibrils in misfolding diseases. In: Gomes, Cláudio M (ed.) Protein misfolding diseases. Humana Press, New York, NY, pp. 109-122. ISBN 9781493988198



Workshop and Conference Attended

2018 UK Protein disulphide bonds: biochemistry, biotechnology and biomedical impact Conference

Affiliations

Alzheimer Research UK south coast network
Biochemical society, UK
Royal Society of Biology (RSB)
Iraqi Society of Clinical Biochemistry

Presentation given

2018
Alzheimer’s disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linking
UK, University of Kent
Event: Protein disulphide bonds: biochemistry, biotechnology and biomedical impact conference
Prizes, Grants and Awards

Other Awards

Jul 2018
Biochemical Society Early Career Bursary