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Tsamo Tontsa Armelle

Country of origin: Cameroon Currently in: Cameroon, Yaounde General field of specialization: Chemical Sciences
Academic Background

Degrees

2014 Doctorate Chemical Sciences
Research and Profession

Current Research Activities

Chemical Sciences

My research lies mainly in the field of natural product structural studies, with emphasis on the indigenous medicinal plants of Cameroon and their associated microorganisms. This field of study generally involves the extraction of plant materials, chromatographic isolation of compounds, NMR structure elucidation, chemical modification of natural products, and biological evaluation of pure compounds and their derivatives. In cases where potential therapeutic agents are discovered, synthesis and/or semi-synthesis will be carried out to study structure-activity relationships with the aim of uncovering analogues with improved biological activity.


Publications resulting from Research: 


18. Gabriele S., Tsamo T. A., Gwladys A. M. C., Pamela K. N., Nazish S., Adriana B., Joseph C. W., Augustin E. N., David A. S. (2019). Vismione B interferes with Trypanosoma cruzi infection of Vero cells and human stem cell-derived cardiomyocytes. American Journal of Traditional Medicine and Hygiene. In press

17. Tsamo T. A., Mustapha M., Peter P. N., Felix D. D. (2019). Identification and quantification of anthocyanins in seeds of Kersting’s groundnut [Macrotyloma geocarpum (Harms) Marechal & Baudet] landraces of varying seedcoat pigmentation. Journal of Food Measurement and Characterisation, DOI: 10.1007/s11694-019-00150-3.

16. Tsamo T. A., Pagna I.J., Nangmo K. ., Mkounga P., Hartmut L., Nkengfack A. E. (2019). Rubescins F–H, new vilasinin-type limonoids from the leaves of Trichilia rubescens (Meliaceae). Zeitschrift für Naturforschung C, DOI: 10.1515/znc-2018-0187.

15. Tsamo T. A., Mohammed H., Ndibewu P. P., Dakora F. D. (2018). Metabolic profiling in the seed coats from differently coloured cowpea growing in Ghana using UPLC-ESI-QTOF-MS-based coupled to multivariate analysis. Natural product Research, in press https://doi.org/10.1080/14786419.2018.1548463.

14. Melong R., Dzoyem J. P., Tsamo T. A., Kapche D. G. W. F., Ngadjui B. T., Lyndy J. M., Eloff J. N. (2018). Inhibitory effect of four naturally occurring compounds from Epiccocum nigrum on acetylcholinesterase activity and nitric oxide production in LPS-activated RAW 264.7 cells. Investigational Medicinal Chemistry and Pharmacology, 1(2):18

13. Tsobnang P. K., Tsamo T. A., Mkounga P., Nkengfack E. A., Kenfack I. T. (2018). Crystal structure of limonoid TS3, isolated from Trichilia rubescens. Acta Cristallographica E, E74, 1083–1086

12. Tsamo T. A., Ndibewu P. P., Dakora F. D. (2018). Phytochemical profile of seeds from 21 Bambara groundnut landraces via UPLC-qTOF-MS. Food Research International, 112: 160–168.

11. Tsamo T. A., Melong R., Mkounga P., Nkengfack A. E. (2018). Rubescins I and J, further limonoid derivatives from the stem bark of Trichilia rubescens (Meliaceae). Natural Product Research, DOI: 10.1080/14786419.2018.1443087.

10. Nangmo K. P., Tsamo T. A., Zhen L., Mkounga P., Akone S. H., Tsabang N., Werner E. G. M., Proksch P., Nkengfack A. E. (2018). Chemical constituents from leaves and root bark of Trichilia monadelpha (Meliaceae). Phytochemistry Letters, 23: 120-126

9. Nangmo K. P., Akone S. H., Tsamo T. A., Zhen L., Werner E. G. M., Proksch P., Nkengfack Augustin Ephrem (2017). Colletotrin: a new sesquiterpene lactone from endophytic fungus Colletetrichum gloesporioides. Z. Naturforchung B, 72(10) b: 697–703.

8. Dzoyem J. P., Melong R., Tsamo T. A., Kapche D., Ngadjui B., McGaw L. J., Eloff J. N. (2017). Cytotoxicity, Antimicrobial and Antioxidant activity of compound isolated from Entada abyssinica (Fabaceae). BMC Research Notes 10:118, DOI 10.1186/s13104-017-2441-z.

7. Dzoyem J. P., Melong R., Tsamo T. A., Maffo T., Kapche D., Ngadjui B., McGaw L. J., Eloff J. N. (2017). Cytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica. Brazilian Journal of Pharmacognosy, 27 (2), 251-253.

6. Lange N., Tsamo T. A., Wegscheid C., Mkounga P., Nkengfack A. E., Tiegs G., Sass G. (2016). Limonoids TS3 and Rubescin E induce apoptosis in human hepatoma cell lines and interfere with NFkB signalling. PLoS ONE 11(8): e0160843.

5. Tsamo T. A., Nangmo K. P., Mkounga P., Müller I. B., Kirk M., Hultin P. G., Sass G., Nkengfack A. E. (2016). Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae). Medicinal Chemistry, 12, (7) 655-6613.

4. Dzoyem J.P., Tsamo T. A., Melong R., Mkounga P., Nkengfack A. E., McGaw L. J., Eloff J. N. (2015). Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschia (Meliaceae). Biological Research, 48:57.

3. Lange N., Tsamo T. A., Horst A. K., Nkengfack A. E., Tiegs G., Sass G. (2014). The limonoids TR4 and TR9 induce apoptosis in mouse and human hepatoma cell lines. Z. Gastroenterology, 52, 44-48. DOI: 10.1055/s-0033-136100

2. Tsamo T. A., Mkounga P., Njayou F. N., José E. M., Kirk M., Hultin G. P., Nkengfack A. E. (2013). Rubescins A, B and C: Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae). Chemical and Pharmaceutical Bulletin, 61 (11), 1178-1183.

1. Tsamo T. A., Langat M. K., Mkounga P., Kamdem W. A. F., Nkengfack A. E., D. A. Mulholland (2013). Limonoids from the West African Trichilia welwistchii (Meliaceae). Biochemical Systematics and Ecology, 50, 368-370.