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Membership type: full

Thais Bascuas

Country of origin: Uruguay Currently in: Switzerland, Geneva General field of specialization: Structural, Cell and Molecular Biology
Academic Background

Degrees

2017 Doctorate Structural, Cell and Molecular Biology
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

I began my career in the field of biomedical sciences with a bachelors and posterior Master degree in molecular biology and microbiology. I subsequently pursued a Ph.D. in Biological Science, acquiring extensive knowledge of immunology, particularly related to tumors and cancer vaccination. At present, I work as a post-doc in the Laboratoire d’Ophtalmologie Expérimentale from the University of Geneva. The main topic of study is the development of regenerative and personalized therapies such as cell-based, GMP compliant Advanced Therapy Medicinal Products (ATMP) to treat neurodegenerative diseases of the eye.

Research Keywords: 
immunology
gene therapy
oncology
molecular biology
Molecular Virology and Microbiology

Publications resulting from Research: 


Peer reviewed Journals
1. Vola M., Mónaco A., Bascuas T., Rimsky G., Agorio C.I., Chabalgoity J.A., Moreno M. TLR7 agonist in combination with Salmonella as an effective antimelanoma immunotherapy. Immunotherapy. 2018. 10:665-679. doi: 10.2217/imt-2017-0188

2. Bascuas T., Moreno M., Grille S., Chabalgoity J.A. Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice. 2018. Frontiers in Immunology. 9:7. doi: 10.3389/fimmu.2018.00007

3. Bascuas, T., Moreno M., Mónaco A., Reyes L., Paolino A., Oliver P., Kramer M.G., Engler H., Pacheco J.P., Grille S., Chabalgoity J.A. A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario. J. Transl. Med. 2016. 14:323. doi: 10.1186/s12967-016-1073-8

4. Grille, S., Moreno M., Bascuas T., Marqués J.M, Muñoz N., Lens D., Chabalgoity J.A. Salmonella enterica serovar Typhimurium immunotherapy for B-Cell Lymphoma induces broad antitumor immunity with therapeutic effect. Immunology. 2014. 143:428-37.doi: 10.1111/imm.12320

5. Azpiroz, M.F., Bascuas, T., Laviña, M. 2011. Microcin H47 system: an Escherichia coli small genomic island with novel features. PLoS ONE. 6: e26179. doi: 10.1371/journal.pone.0026179

Abstracts in meeting proceedings
6. Bascuas, T., Harmening N., Kropp M., Sealy G., Conti A., Wong B., Zedira H., Thumann G. Non-virally transfected primary human pigment epithelium cells overexpressing the oxidative stress reduction factors PEDF and GM-CSF to treat retinal neurodegeneration. ESGCT Annual Congress in collaboration with SETGyC. Barcelona, Spain. 10/2019. Poster P318

7. Bascuas, T., Kropp M., Harmening N., Tobalem S., Midroit M., Conti A., Asrih M., Sealy G., Thumann G. Non-viral transfections with the neuroprotective factors PEDF and GM-CSF reduces oxidative stress in human pigment epithelium cells in vitro offering a promising approach to treat avascular age-related macular degeneration. ESGCT Annual Congress in collaboration with ISSCR and SFTCG. Lausanne, Switzerland. 10/2018. Book abstracts pag. A88. Poster P205

8. Kropp, M., Harmening N., Bascuas T., Sealy G., Conti A., Johnen S., Izsvák Z., Marie C., Scherman D., Ronchetti M., Aranda P., van den Berg J., Thumann G. GMP-grade production of tIPE, a cell-based gene therapy product to treat neovascular age-related macular degeneration (nvAMD) developed in the TargetAMD project. ESGCT Annual Congress in collaboration with ISSCR and SFTCG. Lausanne, Switzerland. 10/2018. Book abstracts pag. A69. Poster P142

9. Bascuas, T., Harmening N., Kropp M., Tobalem S., Midroit M., Conti A., Asrih M., Sealy G., Thumann G. Co-transfection of human Pigment Epithelium cells to express the neuroprotective factors PEDF and GM-CSF to treat nonvascular age-related macular degeneration. 111e SSO Annual Congress. Fribourg, Switzerland. 08/2018. Book abstracts pag. S41. Free paper 2303


10. Grille, S., Bascuas T., Moreno M., Brugnini A., Mónaco A., Chávez C., Seiler N., Lens D., Chabalgoity J.A. Salmonella como inmunoterapia para Linfoma no Hodgkin B. Congreso Nacional de Biociencias 2017. Montevideo, Uruguay. 05/2017. Book abstracts pag. 284. Poster 0170

11. Bascuas, T., Grille, S., Moreno, M., Reyes, L., Paolino A., and Chabalgoity, J.A. Salmonella enterica serovar Typhimurium combined with CHOP chemotherapy for non Hodgkin Lymphoma. IMMUNOCOLOMBIA2015 ‐ 11th Congress of the Latin American Association of Immunology. Medellín, Colombia. 10/2015. Abstract published in Front. Immunol. Poster PO-085

12. Bascuas, T., Grille, S., Moreno, M., Chávez, C., Seiler, N. y Chabalgoity, J.A. “Desarrollo de un modelo murino de Enfermedad Mínima Residual de Linfoma no-Hodgkin B”. XIII Congreso Uruguayo de Hematología. Punta del Este, Uruguay. 11/2014. Book abstracts pag. 43. Poster 18

13. Bascuas, T., Grille S., Moreno M. y Chabalgoity J.A. “Modelo murino de baja carga tumoral de Linfoma no-Hodgkin a células B”. XV Jornadas de la Sociedad Uruguaya de Biociencias (SUB). Piriápolis, Uruguay. 09/2014. Book abstracts pag. 108. Poster S2_046

14. Bascuas, T. y Azpiroz, M.A. “Movilidad de una pequeña isla genómica”. XX Congreso Latinoamericano de Microbiología. IX Encuentro Nacional de Microbiólogos. Montevideo, Uruguay. 09/2010. Book abstracts pag. 127. Poster G-010



Current profession

Current professional activities type: 
Research
At present, I work as a post-doc in the Laboratoire d’Ophtalmologie Expérimentale from the University of Geneva. The main topic of study is the development of regenerative and personalized therapies such as cell-based, GMP compliant Advanced Therapy Medicinal Products (ATMP) to treat neurodegenerative diseases of the eye.