Adeola Folasade EhigieCountry of origin: Nigeria Currently in: Nigeria, Ogbomoso, Oyo State General field of specialization: Biological Systems and Organisms
PhD Fellowship Alumna
Degrees2016 Undergraduate Biological Systems and Organisms2004 Master Biological Systems and Organisms2016 Doctorate Biological Systems and Organisms
Current Research Activities
Biological Systems and Organisms
Mitochondrial bioenergetics as it relates to Programmed Cell Death (Apoptosis). Because of the established link between Momordica charantia (M. charantia)-induced apoptosis and induction of the Mitochondrial Membrane Permeability Transition Pore (MMPTP) opening. Present research efforts are towards determining the anticancer effects of some active compounds of M. charantia via the mitochondrial (intrinsic) pathway.
Current professionCurrent professional activities type:ResearchTeachingI currently teach Biochemistry in a University of Technology here in Nigeria
Fellowship with OWSD
Fellowship with OWSD
Fellowship awarded 2013
PHD Graduation 2016In 2013, I won the OWSD Postgraduate Award to pursue a part-time (‘sandwich’) PhD research program at the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, under the supervision of Prof Xiyun Yan, the Director of the Key Laboratory of Protein and Peptide Pharmaceuticals. As part of the research work leading to the award of a PhD, my work centered on the medicinal plant Momordica charantia (MC) and its effects on selected cancer cell lines (Cervical, Breast and Lung). The cytotoxic effects of some fractions derived from the crude water-soluble extract of MC (Ethylacetate, Dichloromethane, N-hexane, Butanol and aqueous) were established and the mechanism of these effects were elucidated. In contributing to knowledge, our research showed light on the fact that our plant of interest has the ability to kill cancer cell lines and also that the most potent of the fractions tested is the ethylacetate fraction. Also, we confirmed that the mode of death induced by these fractions is non apoptotic though mitochondrial-dependent. A number of Publications have since emanated from the research efforts.Thesis
MODULATION OF MITOCHONDRIAL-DEPENDENT CELL DEATH IN SELECTED CANCER CELL LINES BY PURIFIED COMPOUNDS FROM Momordica charantia LINNAEUSPublications resulting from FellowshipCareer development since receiving OWSD Fellowship
I have bagged a PhD Degree and have been promoted to the rank of a Senior Lecturer. I have vigorously pursued research work and have been able to publish a number of scientific Papers.