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Membership type: full

Nancy Hakooz

Country of origin: Jordan Currently in: Jordan, Amman General field of specialization: Biological Systems and Organisms
Academic Background


1997 Doctorate Biological Systems and Organisms
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

1- Phenotyping/genotyping of the Jordanian population for drug metabolic enzymes. 2- Studying genetically isolated subpopulations in Jordan: Circassians and Chechans. 3- Scaling Factors: Quantitative prediction of in vivo drug clearance from in vitro data from microsomes and hepatocytes in both rats and humans. This line of research was conducted during visits to Professor Brian Houston’s laboratory in the University of Manchester, Manchester, UK. 4- Public Health: The Jordanian population is not a well-characterized population. Screening of the Jordanian population on the national level in different aspects will be very expensive. The only alternative is to conduct such screening on a smaller level for example in different areas of Jordan. This will add to the knowledge of the public health status in general. Along this line of research the prevalence of vitamin B12 and folate deficiency in two ethnic groups in Amman: Arab and Circcasian were investigated. 5- Cell Culture: Participating in the establishment of a cell culture lab for the use of validated cell culture systems for the assessment of drug toxicity and transport. This lab is going to be extended in the future to include drug metabolism studies.

Publications resulting from Research: 

1. AL-Eitan L., Rababa'h D., Hakooz N., Alghamdi MA., Dajani R. (2020) Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan. Journal of Personalized Medicine (JPM), 6(10):1.
2. Al-Eitan L., Saadeh H., Alnaamneh A., Darabseh S., Al-Sarhan N., Alzihlif M., Hakooz N., Ivanova E., Kelsey G., Dajani R. (2020) The genetic landscape of Arab Population, Chechens and Circassians subpopulations from Jordan through HV1 and HV2 regions of mtDNA. Gene 1(729):144314. doi: 10.1016/j.gene.2019.144314.
3. AL-Eitan LN., Darwish NN., Hakooz NM. and Dajani RB. (2020) Investigation of the forensic GlobalFiler loci in the genetically isolated Circassian subpopulation in Jordan. Gene, 5(733):144269. doi: 10.1016/j.gene.2019.144269.
4. AL-Eitan L., Darwish N., Hakooz N. and Dajani R. (2019) Assessing the forensic efficiency of the GlobalFiler STR loci among the genetically isolated Chechen subpopulation in Jordan. Gene 15(720):144078. doi: 10.1016/j.gene.2019. 144078.
5. Al-Eitan LN., Mohammad NN., Al-Maqableh HW., Hakooz NM., Dajani RB. (2019) Genetic Polymorphisms of Pharmacogenomic VIP Variants in the Circassian Subpopulation from Jordan. Current Drug Metabolism, 20(8):674-681. doi: 10.2174/1389200220666190729124000.
6. Abudahab S., Hakooz N., Jarrar Y., Al Shahhab M., Saleh A., Zihlif M. and Dajani R. (2019) Interethnic variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population. Current Drug Metabolism, 20(5):399-410. doi: 10.2174/1389200220666190528085151.
7. Rjoub M., Saleh A., Hakooz N, Imraish A., Jarrar Y. and Zihlif M. (2018) Allelic frequency of PON1 Q192R, CYP2C19* 2 and CYP2C19* 17 among Jordanian patients taking clopidogrel. Tropical Journal of Pharmaceutical Research, 17(11):2275-80.
8. Hakooz N., Jarrar YB., Zihlif M., Imraish A., Hamed S. and Arafat T. (2017) Effects of the genetic variants of organic cation transporters 1 and 3 on the pharmacokinetics of metformin in Jordanians. Drug Metabolism and Personalized Therapy, 2017 Sep 26;32(3):157-162. doi: 10.1515/dmpt-2017-0019.
9. Dajani R., Li J., Wei Z., March ME., Xia Q., Khader Y., Hakooz N., Fatahallah R., El-Khateeb M., Arafat A., Saleh T., Dajani AR., Al-Abbadi Z., Abdul Qader M., Shiyab AH., Bateiha A., Ajlouni K. and Hakonarson H. (2017) Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations. Peer Journal, Aug 17;5:e3618. doi: 10.7717/peerj.3618.
10. Dajani R., Li J., Wei Z., Glessner J., Chang X., Cardinale C., Hakooz N., Khader Y., Sheshani A., Zandaki D. and Hakonarson H. (2015) CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations. Scientific Reports 21; 5:13391. doi: 10.1038/srep13391.
11. Dajani R., Fathallah R., Arafat A, Abdulqader ME., Hakooz N., Al-Motassem Y. and El Khateeb M. (2013) Prevalence of MTHFR C677T Single Nucleotide Polymorphism in Genetically Isolated Populations in Jordan. Biochemical Genetics, 51(9-10): 780-788.
12. Dajani R., Arafat A., Hakooz N., Al-Abbadi Z., Yousef AM., El Khateeb M. and Quadan F. (2013) Polymorphisms in Factor II and Factor V thrombophilia genes among Circassians in Jordan. Journal of Thromobosis and Thrombolysis, 35(1): 83-89.
13. Yousef AM., Bulatova NR., Newman W., Hakooz N., Ismail S., Qusa H., Zahran F., Anwar Ababneh N., Hasan F., Zaloom I., Khayat G., Al-Zmili R., Naffa R., Al-Diab O. (2012) Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population. Molecular Biology Reports. 39(10): 9423-33.
14. Hakooz N., Alzubiedi S., Yousef A., Arafat T., Dajani R., Ababneh N. and Ismail S. (2012) UDP-Glucuronosyltransferase 1A4 (UGT1A4) Polymorphisms In A Jordanian Population. Molecular Biology Reports, 39(7):7763-8.
15. Hakooz N. and Salem I. (2012) Prevalence of Desloratadine Poor Metabolizers Phenotype in Healthy Jordanian Males. Biopharmaceutics and Drug Disposition, 33(1); 15-21.
16. Zalloum I., Hakooz N. and Arafat T (2012). Genetic polymorphism of CYP2C19 in a Jordanian population: influence of allele frequencies of CYP2C19*1 and CYP2C19*2 on the pharmacokinetic profile of lansoprazole. Molecular Biology Reports, 39(4); 4195-200.
17. Hakooz N., Arafat T., Payne D., Ollier W., Pushpakom S., Andrews J. and Newman W. (2010). Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population. European Journal of Clinical Pharmacology, 66; 999-1003.
18. Hakooz N. (2009). Caffeine Metabolic Ratios for the In Vivo Evaluation of CYP1A2, N-acetyltransferase 2, Xanthine Oxidase and CYP2A6 Enzymatic Activities. Current Drug Metabolism, 10; 329-38.
19. Hakooz N. and Hamdan I. (2007). Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Current Drug Metabolism, 8; 9-15.

Current profession

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