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Nehal Hamdy

Country of origin: Egypt Currently in: Egypt, Cairo General field of specialization: Chemical Sciences
Academic Background


1993 Doctorate Chemical Sciences
Research and Profession

Current Research Activities

Chemical Sciences

• Experience in synthetic and medicinal organic chemistry; The Synthesis of heterocyclic compounds of expected biological activities. • Extensive use and interpretation of instrumental data, including Mass, IR, UV, 1HNMR and 13CNMR analyses.

Publications resulting from Research: 

[1] Synthesis and in vitro anticancer evaluation of novel pyridine derivatives bearing tetrahydronaphthalene scaffold. Eman Kh. Hamza, Nehal A. Hamdy, Eman S. Zarie, Issa M. I. Fakhr, Ahmed H. M. Elwahy, Hanem M. Awad, Arkivoc 2019, part VI, 459-480.
[2] Hamza EK, Hamdy NA, Zarie ES, Fakhr IMI, Elwahy AHM, Awad HM. /Synthesis and in vitro evaluation of novel tetralinpyrazolo[3,4-b]pyridine hybrids as potential anticancer agents. J Heterocyclic Chem. 2020; 57:–196. 10.1002/jhet.3764.
[6] Induction of Intrinsic Apoptosis Pathway in Colon Cancer HCT-116 Cells by Novel 2-Substituted-5,6,7,8-Tetrahydronaphthalene Derivatives. Amira M. Gamal-Eldeen, Nehal A. Hamdy, Hatem A. Abdel-Aziz, Enas A. El-Hussieny and Issa M. I. Fakhr. European Journal of Medicinal Chemistry 77 (2014) 323-333.
[7] In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells. Florence Lefranc, Genoveffa Nuzzo, Nehal Aly Hamdy, Issa Fakhr, Laetitia Moreno Y Banuls, Gwendoline Van Goietsenoven, Guido Villani, Véronique Mathieu, Rob van Soest, Robert Kiss, and Maria Letizia Ciavatta. J. Nat. Prod., 76, 1541−1547, (2013).
[8] Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties. Nehal A. Hamdy, Manal M. Anwar, Khadiga Mm. Abu-zied and Hanem M. Awad. Acta Poloniae Pharmaceutica - Drug Research, Vol. 70 No. 6 pp. 987-1001, (2013).
[9] Synthesis and Antiviral Evaluation of Some Novel Pyrazoles and Pyrazolo[3,4-d]pyridazines Bearing the 5,6,7,8-Tetrahydronaphthalene Moiety. Nehal A. Hamdy, Waled M. El- Senousy. Acta Poloniae Pharm. Drug Research. vol. 70 No. 1 pp. 99-110 (2013).
[10] Convenient synthesis, anti-inflamatory, analgesic and ulcerogenic activities of some new bis-hydrazone and pyrazole derivatives. Nehal A. Hamdy*, Hatem A. Abdel-Aziz, Gehan M. Kamel and Issa M. I. Fakhr. Acta Poloniae of Pharm. Drug. Acta Poloniae Pharmaceutica - Drug Research, Vol. 70, No. 3, pp. 469-480, (2013).
[11] Enaminone as Building Blocks in Organic Chemistry: a Novel Route to Polyfunctionally 2- substituted 5, 6, 7, 8-tetrahydronaphthalenes and their Antiviral Evaluation. Nehal A. Hamdy *, Waled M. El- Senousy, and Issa M. I. Fakhr. J. Heterocyclic Chem., 50, 337(2013).
[16] Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8- tetrahydronaphthalene derivatives. Nehal A. Hamdy, Amira M.Gamal-eldeen, Hatem A. Abdelaziz, I M. I. Fakhr, European Journal of Medicinal Chemistry, 45 (2010) 463-470.
[17] New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in simulated RAW 264.7 murine macrophage. Nehal A. Hamdy, Amira M. Gamal-Eldeen. European Journal of Medicinal Chemistry 44 (2009) 4547-4556. It is the top 10 articles published on the same topic, BioMedLib, June 24, 2011.

Current profession

Current professional activities type: 
Head of Applied Organic Chemistry Department. Supervision for a student on Master thesis and Ph.D. thesis Synthesis of heterocyclic compounds of expected biological activities

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