Nimanthi JayathilakaCountry of origin: Sri Lanka Currently in: Sri Lanka, Colombo General field of specialization: Structural, Cell and Molecular Biology
Early Career Fellowship
Degrees2011 Doctorate Structural, Cell and Molecular Biology
Current Research Activities
Structural, Cell and Molecular Biology
Evaluating early molecular markers of severe dengue. Evaluating chemical and nutritional qualities of edible oils and antioxidants.
Publications resulting from Research:
Senanayake C M, Hapugaswatte H, Jayathilaka N, Seneviratne K N (2018) Phenolic extracts of the leaves of Psidium guineense Sw. improve the shelf life of sunflower oil and baked cake and antioxidant status of Wistar rats. Journal of Food Biochemistry.
Prasadani WC, Senanayake C M, Jayathilaka N, Ekanayake S, Seneviratne KN (2017), Effect of three edible oils on the intestinal absorption of caffeic acid: An in vivo and in vitro study. PloS one. Vol 12, Issue 6, e0179292
Krishnananthasivam# S, Jayathilaka# N, Sathkumara H D, Corea E, Natesan M, De Silva A D (2017) Host gene expression analysis in Sri Lankan melioidosis patients. PLOS Neglected Tropical Diseases. 0005643
Wei J, Joshi S, Speransky S, Crowley C, Jayathilaka N, Lei X, Wu Y, Gai D, Jain S, Hoosien M, Gao Y, Chen L, Bishopric N H. (2017) Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface. JCI insight. Vol 2, Issue 17.
Nadeeshani R, Wijayaratna U N, Prasadani W C, Ekanayake S, Seneviratne K N, Jayathilaka N* (2015) Comparison of the Basic Nutritional Characteristics of the First Extract and Second Extract of Coconut Milk, International Journal of Innovative Research in Science, Engineering and Technology. Vol 4, Issue 10, pp. 9516 – 9521
Jayathilaka N*, Weeraratne K S, Buwaneka P A, Dilhani G R S (2015) Epigenetic Modifications in Human Disease, Kalyani Journal of the University of Kelaniya, 2015 Vol. 30, pp. 79
Jayathilaka N*, Han A, Gaffney KJ, Dey R, Jarusiewicz JA, Noridomi K, Philips MA, Lei X, He J, Ye J, Gao T, Petasis NA, Chen L (2012) Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res.
Kalhor R, Tjong H, Jayathilaka N, Alber F, Chen L (2011) Genome architechtures revealed by tethered chromosome conformation capture and population-based modeling. Nature Biotechnol. Vol 30 (1):90-8. Doi: 10.1038/nbt.2057
Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, Chen L (2010) Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. J Mol Biol. Vol 397 (2):520-33. Epub 2010 Feb 2.
Li Z, Luo RT, Mi S, Sun M, Chen P, Bao J, Neilly MB, Jayathilaka N, Johnson DS, Wang L, Lavau C, Zhang Y, Tseng C, Zhang X, Wang J, Yu J, Yang H, Wang SM, Rowley JD, Chen J, Thirman MJ (2009) Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res. 2009 Feb 1;69(3):1109-16. Epub 2009 Jan 20.
Gerr HD, Nassin ML, Davis EM, Jayathilaka N, Neilly ME, Schlegelberger B, Zhang Y, Rowley JD (2007) Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale. Cancer Genet Cytogenet. Vol 176(2):131-6.
Lee S, Chen J, Zhou G, Shi RZ, Bouffard GG, Kocherginsky M, Ge X, Sun M, Jayathilaka N, Kim YC, Emmanuel N, Bohlander SK, Minden M, Kline J, Ozer O, Larson RA, LeBeau MM, Green ED, Trent J, Karrison T, Liu PP, Wang SM, Rowley JD (2006) Gene expression profiles in acute myeloid leukemia with common translocations using SAGE. Proc Natl Acad Sci U S A. Vol 103 (4):1030-5.
Lee S, Johnson D, Dunbar K, Dong H, Ge X, Kim YC, Wing C, Jayathilaka N, Emmanuel N, Zhou CQ, Gerber HL, Tseng CC, Wang SM. (2005) 2.45GHz radiofrequency fields alter gene expression in cultured human cells. FEBS Lett. Vol 579 (21):4829-36.
Zhang Y, Zeleznik-Le N, Emmanuel N, Jayathilaka N, Chen J, Strissel P, Strick R, Li L, Neilly MB, Taki T, Hayashi Y, Kaneko Y, Schlegelberger B, Rowley JD. (2004) Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).Genes Chromosomes Cancer. Vol 41(3):257-65.
Current professionCurrent professional activities type:ResearchTeaching
Fellowship with OWSD
Fellowship with OWSD
Fellowship awarded 2018
Early Career Fellowship awarded awarded