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Member Profile

Membership type: full

Nimanthi Jayathilaka

Country of origin: Sri Lanka Currently in: Sri Lanka, Colombo General field of specialization: Structural, Cell and Molecular Biology
Early Career Fellowship
Academic Background


2011 Doctorate Structural, Cell and Molecular Biology
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

Evaluating early molecular markers of severe dengue. Evaluating chemical and nutritional qualities of edible oils and antioxidants.

Research Keywords: 
Edible oil

Publications resulting from Research: 

 Senanayake C. M., Hapugaswatta H., Samarawickrama G. R., Jayathilaka N and Seneviratne K. N. (2021). Effect of chain length and saturation of the fatty acids in dietary triglycerides on lipid metabolism in Wistar rats, Journal of Food Biochemistry (Accepted for publication)
 Hapugaswatta, H., Wimalasekara, R. L., Perera. S. S., Premaratna, R., Seneviratne, K. N., Jayathilaka, N. (2021). Expression of nitric oxide synthase and nitric oxide levels in peripheral blood cells and oxidized low-density lipoprotein levels in saliva as early markers of severe dengue, Biomed Research International (Accepted for publication)
 Karunasiri A N; Senanayake C M; Hapugaswatta H; Jayathilaka N; Seneviratne K N. (2020). Protective Effect of Coconut Oil Meal Phenolic Antioxidants against Macromolecular Damage: In Vitro and In Vivo Study. Journal of Chemistry DOI: 10.1155/2020/3503165
 Karunasiri A N, Gunawardane M, Senanayake C M, Jayathilaka N, Seneviratne K N, (2020) Antioxidant and Nutritional Properties of Domestic and Commercial Coconut Milk Preparations, International Journal of Food Science, Vol 2020,
 Hapugaswatta, H., Amarasena, P., Premaratna, R., Seneviratne, K. N., Jayathilaka, N. (2020). Differential expression of microRNA, miR150 and enhancer of zeste homolog 2 (EZH2) in peripheral blood cells as early markers of severe forms of Dengue, Journal of Biomedical Science. 27:25,
 Senanayake C M, Hapugaswatte H, Jayathilaka N, Seneviratne K N (2018) Phenolic extracts of the leaves of Psidium guineense Sw. improve the shelf life of sunflower oil and baked cake and antioxidant status of Wistar rats. Journal of Food Biochemistry.
 Prasadani WC, Senanayake C M, Jayathilaka N, Ekanayake S, Seneviratne KN (2017), Effect of three edible oils on the intestinal absorption of caffeic acid: An in vivo and in vitro study. PloS one. Vol 12, Issue 6, e0179292
 Krishnananthasivam# S, Jayathilaka# N, Sathkumara H D, Corea E, Natesan M, De Silva A D (2017) Host gene expression analysis in Sri Lankan melioidosis patients. PLOS Neglected Tropical Diseases. 0005643
 Wei J, Joshi S, Speransky S, Crowley C, Jayathilaka N, Lei X, Wu Y, Gai D, Jain S, Hoosien M, Gao Y, Chen L, Bishopric N H. (2017) Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface. JCI insight. Vol 2, Issue 17.
 Nadeeshani R, Wijayaratna U N, Prasadani W C, Ekanayake S, Seneviratne K N, Jayathilaka N* (2015) Comparison of the Basic Nutritional Characteristics of the First Extract and Second Extract of Coconut Milk, International Journal of Innovative Research in Science, Engineering and Technology. Vol 4, Issue 10, pp. 9516 – 9521
 Jayathilaka N*, Weeraratne K S, Buwaneka P A, Dilhani G R S (2015) Epigenetic Modifications in Human Disease, Kalyani Journal of the University of Kelaniya, 2015 Vol. 30, pp. 79
 Jayathilaka N*, Han A, Gaffney KJ, Dey R, Jarusiewicz JA, Noridomi K, Philips MA, Lei X, He J, Ye J, Gao T, Petasis NA, Chen L (2012) Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res.
 Kalhor R, Tjong H, Jayathilaka N, Alber F, Chen L (2011) Genome architechtures revealed by tethered chromosome conformation capture and population-based modeling. Nature Biotechnol. Vol 30 (1):90-8. Doi: 10.1038/nbt.2057
 Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, Chen L (2010) Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. J Mol Biol. Vol 397 (2):520-33. Epub 2010 Feb 2.
 Li Z, Luo RT, Mi S, Sun M, Chen P, Bao J, Neilly MB, Jayathilaka N, Johnson DS, Wang L, Lavau C, Zhang Y, Tseng C, Zhang X, Wang J, Yu J, Yang H, Wang SM, Rowley JD, Chen J, Thirman MJ (2009) Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res. 2009 Feb 1;69(3):1109-16. Epub 2009 Jan 20.
 Gerr HD, Nassin ML, Davis EM, Jayathilaka N, Neilly ME, Schlegelberger B, Zhang Y, Rowley JD (2007) Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale. Cancer Genet Cytogenet. Vol 176(2):131-6.
 Lee S, Chen J, Zhou G, Shi RZ, Bouffard GG, Kocherginsky M, Ge X, Sun M, Jayathilaka N, Kim YC, Emmanuel N, Bohlander SK, Minden M, Kline J, Ozer O, Larson RA, LeBeau MM, Green ED, Trent J, Karrison T, Liu PP, Wang SM, Rowley JD (2006) Gene expression profiles in acute myeloid leukemia with common translocations using SAGE. Proc Natl Acad Sci U S A. Vol 103 (4):1030-5.
 Lee S, Johnson D, Dunbar K, Dong H, Ge X, Kim YC, Wing C, Jayathilaka N, Emmanuel N, Zhou CQ, Gerber HL, Tseng CC, Wang SM. (2005) 2.45GHz radiofrequency fields alter gene expression in cultured human cells. FEBS Lett. Vol 579 (21):4829-36.
 Zhang Y, Zeleznik-Le N, Emmanuel N, Jayathilaka N, Chen J, Strissel P, Strick R, Li L, Neilly MB, Taki T, Hayashi Y, Kaneko Y, Schlegelberger B, Rowley JD. (2004) Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).Genes Chromosomes Cancer. Vol 41(3):257-65.

Current profession

Current professional activities type: 

Presentation given

Fellowship with OWSD

Fellowship with OWSD

Fellowship with OWSD

Fellowship awarded

Early Career Fellowship awarded 2018

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