You are here

Member Profile

Membership type: full

Arunasree Kalle

Country of origin: India Currently in: India, Hyderabad General field of specialization: Structural, Cell and Molecular Biology
Academic Background


2008 Doctorate Structural, Cell and Molecular Biology
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

Research Keywords: 
Antibiotic resistance
Multidrug resistance
Drug discovery

Publications resulting from Research: 

1. Annamanedi M, Varma GYN, Anuradha K, Kalle AM*. Celecoxib Enhances the Efficacy of Low-Dose Antibiotic Treatment against Polymicrobial Sepsis in Mice and Clinical Isolates of ESKAPE Pathogens. Front Microbiol. 2017 May 8;8:805.
2. Ratna Sudha M, Kalle AM*. Antiproliferative effects of Bacillus coagulans Unique IS2 in colon cancer cells. Nutrition and Cancer. 2017 Article in Press.
3. Pidugu VR, Yarla NS, Bishayee A, Kalle AM, Satya AK. Novel histone deacetylase 8-selective inhibitor 1,3,4-oxadiazole-alanine hybrid induces apoptosis in breast cancer cells. Apoptosis. 2017 Nov;22(11):1394-1403


4. Yarla NS, Bishayee A, Sethi G, Reddanna P, Kalle AM, Dhananjaya BL, et al. Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. Semin Cancer Biol. 2016;40-41:48-81.
5. Pidugu VR, Yarla NS, Pedada SR, Kalle AM, Satya AK. Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity. Bioorg Med Chem. 2016;24(21):5611-5617.
6. Pedada SR, Yarla NS, Tambade PJ, Dhananjaya BL, Bishayee A, Arunasree KM, Philip GH, Dharmapuri G, Aliev G, Putta S, Rangaiah G. Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents. Eur J Med Chem. 2016; 112:289-97.

7. Korada SK, Yarla NS, Bishayee A, Aliev G, Aruna Lakshmi K, Arunasree MK, et al. Can Probiotics Cure Inflammatory Bowel Diseases? Current pharmaceutical design. 2016;22(7):904-17.
8. Amgoth C, Dharmapuri G, Kalle AM, Paik P. Nanoporous capsules of block co-polymers of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for the controlled release of anticancer drugs for therapeutic applications. Nanotechnology. 2016;27(12):125101.

9. Korada SK, Yarla NS, Bishayee A, Aliev G, Aruna Lakshmi K, Arunasree MK, Dananajaya BL, Mishra V (2015). Can probiotics cure inflammatory bowel diseases? Curr Pharm Des. PMID:26648465.
10. Sudha MR, Arunasree KM*(2015). Anti-inflammatory and immunomodulatory effects of Bacillus coagulans unique IS2. International Journal of Probiotics & Prebiotics 10.
11. Dharmapuri G, Doneti R, Philip GH, Kalle AM* (2015). Celecoxib sensitizes imatinib-resistant K562 cells to imatinib by inhibiting MRP1-5, ABCA2 and ABCG2 transporters via Wnt and Ras signaling pathways. Leuk Res. 2015 Apr 6. pii: S0145-2126(15)00085-5. PMID:25916699
12. Kumar K, Kumar Doddi S, Arunasree MK, Paik P. CPMV-induced synthesis of hollow mesoporous SiO2 nanocapsules with excellent performance in drug delivery. Dalton Trans. 2015 Mar 7;44(9):4308-17. PMID: 25640798
13. Gogireddy S, Kalle AM, Dubey P, Reddy AV. 2014. Design, synthesis and characterization of 1H-pyridin-4-yl-3, 5-disubstituted indazoles and their AKT inhibition activity. Journal of Chemical Sciences 126:1055-1062.
14. Dulla B, Sailaja E, CH UR, Aeluri M, Kalle AM, Bhavani S, Rambabu D, Rao MB, Pal M. 2014. Synthesis of indole based novel small molecules and their in vitro anti-proliferative effects on various cancer cell lines. Tetrahedron Letters 55:921-926.
15. Kumar BV, Lakshmi N, Kumar MR, Rambabu G, Manjashetty TH, Arunasree KM, Sriram D, Ramkumar K, Neamati N, Dayam R, Sarma JA. Design, synthesis and screening studies of potent thiazol-2-amine derivatives as fibroblast growth factor receptor 1 inhibitors. Curr Top Med Chem. 2014;14(17):2031-41. PMID: 25322771
16. Annamanedi M, Kalle AM*. Celecoxib Sensitizes Staphylococcus aureus to Antibiotics in Macrophages by Modulating SIRT1. PLoS One. 2014 Jun 20;9(6):e99285. doi: 10.1371/journal.pone.0099285. eCollection 2014. PubMed PMID: 24950067. PMCID: PMC4064976
17. Reddy Chamakura U, Sailaja E, Dulla B, Kalle AM, Bhavani S, Rambabu D, Kapavarapu R, Rao MV, Pal M. Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1366-72. doi: 10.1016/j.bmcl.2014.01.044. Epub 2014 Jan 26. PubMed PMID: 24513041.
18. Haider S, Alam MS, Hamid H, Shafi S, Nargotra A, Mahajan P, Nazreen S, Kalle AM, Kharbanda C, Ali Y, Alam A, Panda AK. Synthesis of novel 1,2,3-triazole based benzoxazolinones: Their TNF-α based molecular docking with in-vivo anti-inflammatory, antinociceptive activities and ulcerogenic risk evaluation. Eur J Med Chem. 2013 Dec;70:579-88. doi: 10.1016/j.ejmech.2013.10.032. Epub 2013 Oct 22. PubMed PMID: 24211633.
19. Bano S, Javed K, Ahmad S, Rathish IG, Singh S, Chaitanya M, Arunasree KM, Alam MS. Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity. Eur J Med Chem. 2013 Jul;65:51-9. doi: 10.1016/j.ejmech.2013.04.056. Epub 2013 May 3. PubMed PMID: 23693150.
20. Kand D, Kalle AM, Talukdar P. Chromenoquinoline-based thiol probes: a study on the quencher position for controlling fluorescent Off-On characteristics. Org Biomol Chem. 2013 Feb 13;11(10):1691-701. doi: 10.1039/c2ob27192c. PubMed PMID: 23364761.
21. Ravi A, Alvala M, Sama V, Kalle AM, Irlapati VK, Reddy BM. Anticancer activity of Pupalia lappacea on chronic myeloid leukemia K562 cells. Daru. 2012 Dec 5;20(1):86. doi: 10.1186/2008-2231-20-86. PubMed PMID: 23351440; PubMed Central PMCID: PMC3559012. PMCID: PMC3559012
22. Tonk RK, Bawa S, Chawla G, Deora GS, Kumar S, Rathore V, Mulakayala N, Rajaram A, Kalle AM, Afzal O. Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents. Eur J Med Chem. 2012 Nov;57:176-84. doi: 10.1016/j.ejmech.2012.08.045. Epub 2012 Sep 7. PubMed PMID: 23059546.
23. Rambabu D, Mulakayala N, Ismail, Kumar KR, Kumar GP, Mulakayala C, Kumar CS, Kalle AM, Rao MV, Oruganti S, Pal M. Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6745-9. doi: 10.1016/j.bmcl.2012.08.082. Epub 2012 Aug 31. PubMed PMID: 23010270.
24. Manjulatha K, Srinivas S, Mulakayala N, Rambabu D, Prabhakar M, Arunasree KM, Alvala M, Basaveswara Rao MV, Pal M. Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6160-5. doi: 10.1016/j.bmcl.2012.08.017. Epub 2012 Aug 9. PubMed PMID: 22929231.
25. Nakhi A, Adepu R, Rambabu D, Kishore R, Vanaja GR, Kalle AM, Pal M. Thieno[3,2-c]pyran-4-one based novel small molecules: their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4418-27. doi: 10.1016/j.bmcl.2012.04.109. Epub 2012 May 2. PubMed PMID: 22632935.
26. Kumar KS, Rambabu D, Prasad B, Mujahid M, Krishna GR, Rao MV, Reddy CM, Vanaja GR, Kalle AM, Pal M. A new approach to construct a fused 2-ylidene chromene ring: highly regioselective synthesis of novel chromeno quinoxalines. Org Biomol Chem. 2012 Jun 28;10(24):4774-81. doi: 10.1039/c2ob25416f. Epub 2012 May 16. PubMed PMID: 22588576.
27. Ellanki AR, Islam A, Rama VS, Pulipati RP, Rambabu D, Krishna GR, Reddy CM, Mukkanti K, Vanaja GR, Kalle AM, Kumar KS, Pal M. Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): synthesis of novel triazolyl substituted quinolines as potential anticancer agents. Bioorg Med Chem Lett. 2012 May 15;22(10):3455-9. doi: 10.1016/j.bmcl.2012.03.091. Epub 2012 Mar 30. PubMed PMID: 22516283.
28. Shafi S, Alam MM, Mulakayala N, Mulakayala C, Vanaja G, Kalle AM, Pallu R, Alam MS. Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities. Eur J Med Chem. 2012 Mar;49:324-33. doi: 10.1016/j.ejmech.2012.01.032. Epub 2012 Jan 24. PubMed PMID: 22305614.
29. Kand D, Kalle AM, Varma SJ, Talukdar P. A chromenoquinoline-based fluorescent off-on thiol probe for bioimaging. Chem Commun (Camb). 2012 Mar 11;48(21):2722-4. doi: 10.1039/c2cc16593g. Epub 2012 Feb 3. PubMed PMID: 22301487.
30. Chandramohan Reddy T, Bharat Reddy D, Aparna A, Arunasree KM, Gupta G, Achari C, Reddy GV, Lakshmipathi V, Subramanyam A, Reddanna P. Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation. Toxicol In Vitro. 2012 Apr;26(3):396-405. doi: 10.1016/j.tiv.2011.12.018. Epub 2012 Jan 8. PubMed PMID: 22245431.
31. Mulakayala N, Rambabu D, Raja MR, M C, Kumar CS, Kalle AM, Rama Krishna G, Malla Reddy C, Basaveswara Rao MV, Pal M. Ultrasound mediated catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones leading to novel quinoline derivatives: their evaluation as potential anti-cancer agents. Bioorg Med Chem. 2012 Jan 15;20(2):759-68. doi: 10.1016/j.bmc.2011.12.001. Epub 2011 Dec 8. PubMed PMID: 22202437.
32. Reddy CB, Kumar KS, Kumar MA, Narayana Reddy MV, Krishna BS, Naveen M, Arunasree MK, Reddy CS, Raju CN, Reddy CD. PEG-SO(3)H catalyzed synthesis and cytotoxicity of α-aminophosphonates. Eur J Med Chem. 2012 Jan;47(1):553-9. doi: 10.1016/j.ejmech.2011.11.026. Epub 2011 Nov 20. PubMed PMID: 22136905.
33. Rao RM, Reddy UC, Alinakhi, Mulakayala N, Alvala M, Arunasree MK, Poondra RR, Iqbal J, Pal M. Sequential coupling/desilylation-coupling/cyclization in a single pot under Pd/C-Cu catalysis: synthesis of 2-(hetero)aryl indoles. Org Biomol Chem. 2011 May 21;9(10):3808-16. doi: 10.1039/c0ob01161d. Epub 2011 Mar 29. PubMed PMID: 21448470.
34. Layek M, Reddy M A, Rao AV, Alvala M, Arunasree MK, Islam A, Mukkanti K, Iqbal J, Pal M. Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes. Org Biomol Chem. 2011 Feb 21;9(4):1004-7. doi: 10.1039/c0ob00771d. Epub 2010 Dec 23. PubMed PMID: 21180745.
35. Kalle AM*, Rizvi A. Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor. Antimicrob Agents Chemother. 2011 Jan;55(1):439-42. doi: 10.1128/AAC.00735-10. Epub 2010 Oct 11. PubMed PMID: 20937780; PubMed Central PMCID: PMC3019655.
36. Kalle AM*, Mallika A, Badiger J, Alinakhi, Talukdar P, Sachchidanand. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9. doi: 10.1016/j.bbrc.2010.08.118. Epub 2010 Sep 15. PubMed PMID: 20813094.
37. Kalle AM*, Sachchidanand S, Pallu R. Bcr-Abl-independent mechanism of resistance to imatinib in K562 cells: Induction of cyclooxygenase-2 (COX-2) by histone deacetylases (HDACs). Leuk Res. 2010 Sep;34(9):1132-8. doi: 10.1016/j.leukres.2010.01.030. Epub 2010 Mar 5. PubMed PMID: 20206383.
38. Arunasree KM*. Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine. 2010 Jul;17(8-9):581-8. doi: 10.1016/j.phymed.2009.12.008. Epub 2010 Jan 22. PubMed PMID: 20096548.
39. Kumar KA, Arunasree KM, Roy KR, Reddy NP, Aparna A, Reddy GV, Reddanna P. Effects of (15S)-hydroperoxyeicosatetraenoic acid and (15S)-hydroxyeicosatetraenoic acid on the acute- lymphoblastic-leukaemia cell line Jurkat: activation of the Fas-mediated death pathway. Biotechnol Appl Biochem. 2009 Feb;52(Pt 2):121-33. doi: 10.1042/BA20070264. PubMed PMID: 18494609.
40. Arunasree KM, Roy KR, Anilkumar K, Aparna A, Reddy GV, Reddanna P. Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1. Leuk Res. 2008 Jun;32(6):855-64. Epub 2008 Feb 20. PubMed PMID: 18083230.
41. Sreekanth D, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562. Phytomedicine. 2007 Nov;14(11):739-46. Epub 2007 May 7. PubMed PMID: 17482444.
42. Roy KR, Arunasree KM, Dhoot A, Aparna R, Reddy GV, Vali S, Reddanna P. C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and In silico analysis. Arch Biochem Biophys. 2007 Mar 15;459(2):169-77. Epub 2007 Jan 29. PubMed PMID: 17303067.
43. Roy KR, Arunasree KM, Reddy NP, Dheeraj B, Reddy GV, Reddanna P. Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicinresistant human hepatocellular-carcinoma cell line HepG2. Biotechnol Appl Biochem. 2007 Jul;47(Pt 3):159-67. PubMed PMID: 17274761.

Current profession

Current professional activities type: 
Teaching master students and Doctorate students Research

Search form