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Member Profile

Membership type: full

Catherine Kegakilwe Koofhethile

Country of origin: Botswana Currently in: United States, Boston General field of specialization: Medical and Health Sciences incl Neurosciences
PhD Fellowship Alumna
Academic Background

Degrees

2016 Doctorate Medical and Health Sciences incl Neurosciences
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

Assessment of the HIV reservoir during long term antiretroviral therapy.


Publications resulting from Research: 


1. Undetectable proviral deoxyribonucleic acid in an adolescent perinatally infected with human immunodeficiency virus-1C and on long-term antiretroviral therapy resulted in viral rebound following antiretroviral therapy termination: A case report with implications for clinical care.
Koofhethile CK, Moyo S, Kotokwe KP, Mokgethi P, Muchoba L, Mokgweetsi S, Gaolathe T, Makhema J, Shapiro R, Lockman S, Kanki P, Essex M, Gaseitsiwe S, de Oliveira T, Novitsky V. Medicine (Baltimore). 2019 Nov;98(47):e18014. doi: 10.1097/MD.0000000000018014. PMID: 31764816 Free Article
2. CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. Koofhethile CK, Ndhlovu ZM, Thobakgale-Tshabalala C, Prado JG, Ismail N, Mncube Z, Mkhize L, van der Stok M, Yende N, Walker BD, Goulder PJR, Ndung'u T. J Virol. 2016 Jul 11;90(15):6818-6831. doi: 10.1128/JVI.00276-16. Print 2016 Aug 1. PMID: 27194762 Free PMC Article

3. CD8+ TCR Bias and Immunodominance in HIV-1 Infection.
Kløverpris HN, McGregor R, McLaren JE, Ladell K, Harndahl M, Stryhn A, Carlson JM, Koofhethile C, Gerritsen B, Keşmir C, Chen F, Riddell L, Luzzi G, Leslie A, Walker BD, Ndung'u T, Buus S, Price DA, Goulder PJ. J Immunol. 2015 Jun 1;194(11):5329-45. doi: 10.4049/jimmunol.1400854. Epub 2015 Apr 24. PMID: 25911754 Free PMC Article

4. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. Kløverpris HN, McGregor R, McLaren JE, Ladell K, Stryhn A, Koofhethile C, Brener J, Chen F, Riddell L, Graziano L, Klenerman P, Leslie A, Buus S, Price DA, Goulder P. AIDS. 2014 Sep 10;28(14):2007-21.
PMID: 24906112 Free PMC Article

5. Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints. Payne RP, Branch S, Kløverpris H, Matthews PC, Koofhethile CK, Strong T, Adland E, Leitman E, Frater J, Ndung'u T, Hunter E, Haubrich R, Mothe B, Edwards A, Riddell L, Chen F, Harrigan PR, Brumme ZL, Mallal S, John M, Jooste JP, Shapiro R, Deeks SG, Walker BD, Brander C, Landis C, Carlson JM, Prado JG, Goulder PJ. J Virol. 2014 May;88(9):4668-78. doi: 10.1128/JVI.03303-13. Epub 2014 Feb 5. PMID: 24501417 Free PMC Article

6. Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.
Ndhlovu ZM, Piechocka-Trocha A, Vine S, McMullen A, Koofhethile KC, Goulder PJ, Ndung'u T, Barouch DH, Walker BD. J Immunol. 2011 Jun 15;186(12):6914-24. doi: 10.4049/jimmunol.1004231. Epub 2011 May 16. PMID: 21576505 Free PMC Article

7. HLArestrictor--a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides. Erup Larsen M, Kloverpris H, Stryhn A, Koofhethile CK, Sims S, Ndung'u T, Goulder P, Buus S, Nielsen M.
Immunogenetics. 2011 Jan;63(1):43-55. doi: 10.1007/s00251-010-0493-5. Epub 2010 Nov 16. PMID: 21079948

8. Prevalence and potential pathogenicity of Vibrio parahaemolyticus in Chinese mitten crabs (Eriocheir sinensis) harvested from the River Thames estuary, England. Wagley S, Koofhethile K, Rangdale R. J Food Prot. 2009 Jan;72(1):60-6. PMID: 19205465

9. Comparison of V. parahaemolyticus isolated from seafoods and cases of gastrointestinal disease in the UK.
Wagley S, Koofhethile K, Wing JB, Rangdale R. Int J Environ Health Res. 2008 Aug;18(4):283-93. doi: 10.1080/09603120801911064. PMID: 18668416



Current profession

Current professional activities type: 
Research
HIV Immunology, HIV reservoir

Workshop and Conference Attended

2014 Durban, South Africa Biostatistics course
2014 Maine, USA Gorgon Research Seminar- Immunobiology/Immunochemistry
2013 Naple, Italy Advanced Vaccine course
2013 Cape Town, South Africa Flow cytometry workshop
2013 Pretoria, South Africa Scientific reading and writing, publishing course by OWSD
2013 Barcelona, Spain AIDS Vaccine conference
2014 Lindau, Germany 64th Lindau Noble laureates meeting Medicine/Physiology

Presentation given

2014
Reduction in the breadth of CD8+ T cell responses is associated with loss of virologic HIV control in individuals with protective HLA alleles.
Cape Town, South Africa
Event: HIV Research 4 Prevention conference (ORAL)
2014
Reduction in breadth and not polyfunctionality or proliferative capacity of CD8+ T cells is associated with loss of virologic HIV control in individuals with protective HLA alleles.
Maine, USA
Event: Gordon Research Conference – Immunobiology/Immunochemistry (POSTER)
2013
Protective HLA alleles: Investigation of viral control and lack of control in chronic HIV-1 subtype C infection.
Cape Town, South Africa
Event: 4th Infectious Diseases in Africa Symposium (POSTER AND ORAL)
2013
Protective HLA alleles: Investigation of viral control and lack of control in chronic HIV-1 subtype C infection.
Durban, South Africa
Event: SA AIDS conference (POSTER)
2013
Protective HLA alleles: Investigation of viral control and lack of control in chronic HIV-1 subtype C infection.
Colorado, USA
Event: Keystone HIV Immune Activation Conference (POSTER)
2014
Protective HLA alleles: Investigation of viral control and lack of control in chronic HIV-1 subtype C infection.
Event: UKZN- Laboratory Medicine and Medical Sciences Reserch Symposium (ORAL)
Prizes, Grants and Awards

Other Awards

Oct 2010
OWSD PhD Fellowship
PhD fellowship
Dec 2016
African-German Network of Excellence in Science (AGNES) Junior Researcher
African-German Network of Excellence in Science (AGNES) Junior Researcher
Fellowship with OWSD

Fellowship with OWSD

Fellowship with OWSD

Fellowship awarded 2010

Early Career Fellowship awarded 2020

PHD Graduation 2016