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Member Profile

Membership type: full

Sarala Manandhar

Country of origin: Nepal Currently in: Nepal, Kathmandu General field of specialization: Medical and Health Sciences incl Neurosciences
Academic Background


2011 Doctorate Medical and Health Sciences incl Neurosciences
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

Bacterial metabolites, Medicinal plant extracts, Cancer Research, Cancer Signaling

Publications resulting from Research: 

1. Park Myo-Hyeon, Kim Ae Kyung, Manandhar Sarala, Oh Su-Young, Jang Gun-Hyuk, Li Kang, Hyeon Do Young, Lee Sun-Hee, Yoon Soo-Hyun, Lee Hye Eun, Lee SeHyung, Hwang Daehee, Byun Kyunghee and Lee You Mie. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. Elife. 2019 Aug 20;8. pii: e46012. doi: 10.7554/eLife.46012.
2. Manandhar Sarala and Lee You Mie. Emerging role of RUNX3 in the regulation of tumor Microenvironment. BMB Rep. 2018, 51(4): 174–181.
3. Manandhar Sarala, Kim Chang-gu, Lee Sun-Hee, Kang Soo Hyun, Basnet Nikita, and Lee You Mie. Exostosin 1 regulates cancer cell stemness in doxorubicin resistant breast cancer cells. Oncotarget. 2017, 3: 8(41):70521-7053. 4. Lee Sun Hee, Manandhar Sarala, and Lee You Mie. Role of RUNX in hypoxiainduced responses and angiogenesis. In: Ito, Y eds. Diverse Roles of RUNX Proteins in Development and Cancer. Adv Exp Med Biol. 2017: 962:449-469.(Equal contribution)
5. Manandhar Sarala, Choi Bo-hyun, Jung Kyeong-Ah, Ryoo In-geun, Song Mingu, Kang Su Jin, Choi Han-Gon, Kim Jung-Ae, Park Pil-Hoon and Kwak Mi- Kyoung. NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity. Free Radic Biol Med. 2012, 52(9):1773-1785.
6. Manandhar Sarala, Lee Sangwhan, and Kwak Mi-Kyoung. Effect of Stable Inhibition of NRF2 on Doxorubicin Sensitivity in Human Ovarian Carcinoma OV90 Cells, Arch Pharm Res. 2010, 33(5):717-726. (Selected by Editors)
7. Shim Gi-seong, Manandhar Sarala, Shin Dong-ha, Kim Tae-Hyoung, Kwak MiKyoung. Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway. Free Radic Biol Med. 2009, 47 (11):1619–1631. (Equal contribution)
8. Manandhar Sarala, You Aram, Lee Eung-Seok, Kim Jung-Ae, Kwak Mi- Kyoung, Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 activator, Journal of Pharmacy and Pharmacology, 2008, 60(7): 879-887.
9. Cho Jeong-Min, Manandhar Sarala, Lee Hyang Rim, Park Hyun Min, Kwak Mi- Kyoung. Role of the Nrf2 antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to Cancer cell resistance; Cancer Lett. 2008, 260 (1-2): 96-108.
10. Manandhar Sarala, Cho Jeong-Min, Kim Jung- Ae, Kensler Thomas W, Kwak Mi- Kyoung. Induction of Nrf2- regulated genes by 3H-1,2- dithiole 3-thione through the ERK signaling pathway in Murine Keratinocyte, European Journal of Pharmacology. 2007, 577 (1-3): 17-27.

Current profession

Current professional activities type: 
Research on Cancer, Teaching graduate students

Workshop and Conference Attended

2020 Pokhara, Nepal 3rd International Conference on Bioscience and Biotechnology
2018 The-K Hotel, Seoul, South Korea The Pharmaceutical Society of Korea
2017 Muju, South Korea Japan-Korea Joint Symposium of Vascular Biology

Presentation given

Exostosin 1 regulates cancer cell stemness by increasing heparin sulfate biosynthesis in doxorubicin resistant breast cancer cells
Event: 7 Lakes Proteoglycans conference
Exostosin 1 regulates cancer cell stemness in breast cancer cells
San Diego, USA
Event: American Association of Cancer Research (AACR)
Exostosin-1 (EXT1) regulates breast cancer cell stemness.
KAIST, South Korea
Event: Matrix Biology Symposium
Resistance to alkylating anticancer drugs: Role of the Nrf2-antioxidant system.
San diego, USA
Event: American Association of Cancer Research (AACR)
Prizes, Grants and Awards

Other Awards

Jul 2017
Research Grant (NRF-2017R1D1A3B03034382)
Research Grant, National Research Foundation (NRF), Government of Korea
Sep 2012
Gold Medal “ Nepal Bidhya Bhusan”
Completion of Phd degree, Ministry of Education, Nepal
Aug 2007
Doctoral dissertation Fellowship (KRF-2007-211-E00012)
PhD Fellowship Award, Korean Research Foundation (KRF), Government of Korea
Dec 2007
Outstanding Poster Award
Outstanding poster in International Association of Environmental Mutagen Societies (IAEMS) Conferance, Jeju, South Korea
Sep 2006
University Scholarship
University Scholarship for PhD studies, Yeungnam University, South Korea

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