Member Profile
Membership type: full
Lucy Mupfumi
Country of origin: Botswana Currently in: Botswana, Gaborone General field of specialization: Medical and Health Sciences incl Neurosciences-
Degrees
2020 Doctorate Medical and Health Sciences incl Neurosciences2014 Master Medical and Health Sciences incl Neurosciences2006 Undergraduate Medical and Health Sciences incl Neurosciences -
Current Research Activities
Medical and Health Sciences incl Neurosciences
I am an infectious disease scientist with a long-standing interest in TB/HIV epidemiology. My research career has revolved around TB/HIV co-infection, epidemiology and diagnostics and over the past 5 years, l have contributed to our understanding of the impact of Xpert MTB/RIF on patient outcomes and described the burden of TB in the Botswana antiretroviral program. My current research utilizes epidemiological models to understand the changing transmission of TB with expanded HIV treatment in Botswana. My long term interest is to lead programmatic efforts that advance TB care and control in low resource, high burden settings.
Publications resulting from Research:
1. Mupfumi L, Mpande CAM, Reid T, Moyo S, Shin SS, Zetola NM, Mogashoa T, Musonda RM, Kasvosve I, Scriba TJ, Nemes E, Gaseitsiwe G. Immune phenotype and functionality of Mtb-specific T-cells in HIV/TB co-infected patients on antiretroviral therapy. Pathogens. 2020,9 (3). PMID 32131556
2. Mupfumi L, Moyo S, Shin SS, Wang Q, Zetola N, Molebatsi K, Nnawa J, Kgwaadira BT, Bewlay L, Chebani T, Iketleng T, Mogashoa T, Makhema J, Musonda RM, Essex M, Kasvosve I, Gaseitsiwe S. High Incidence of tuberculosis in the first year of antiretroviral therapy in the Botswana National ART programme between 2011 and 2015. AIDS. 2019 Sep 3;PubMed PMID: 31490231.
3. Mogashoa T, Melamu P, Ley SD, Streicher EM, Iketleng T, Kelentse N, Mupfumi L, Mokomane M, Kgwaadira B, Novitsky V, Kasvosve I, Moyo S, Warren RM, Gaseitsiwe S. Genetic diversity of Mycobacterium tuberculosis strains circulating in Botswana. PLoS One. 2019;14(5):e0216306. PubMed PMID: 31063472; PubMed Central PMCID: PMC6504092.
4. Di Tanna GL, Khaki AR, Theron G, McCarthy K, Cox H, Mupfumi L, Trajman A, Zijenah LS, Mason P, Bandason T, Durovni B, Bara W, Hoelscher M, Clowes P, Mangu C, Chanda D, Pym A, Mwaba P, Cobelens F, Nicol MP, Dheda K, Churchyard G, Fielding K, Metcalfe JZ. Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis. Lancet Glob Health. 2019 Feb;7(2):e191-e199. PubMed PMID: 30683238; PubMed Central PMCID: PMC6366854.
5. Mupfumi L, Moyo S, Molebatsi K, Thami PK, Anderson M, Mogashoa T, Iketleng T, Makhema J, Marlink R, Kasvosve I, Essex M, Musonda RM, Gaseitsiwe S. Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana. PLoS One. 2018;13(1):e0192030. PubMed PMID: 29385208; PubMed Central PMCID: PMC5792012.
6. Iketleng T, Lessells R, Dlamini MT, Mogashoa T, Mupfumi L, Moyo S, Gaseitsiwe S, de Oliveira T. Mycobacterium tuberculosis Next-Generation Whole Genome Sequencing: Opportunities and Challenges. Tuberc Res Treat. 2018;2018:1298542. PubMed PMID: 30631597; PubMed Central PMCID: PMC6304523.
7. Mupfumi L, Makamure B, Chirehwa M, Sagonda T, Zinyowera S, Mason P, Metcalfe JZ, Mutetwa R. Impact of Xpert MTB/RIF on Antiretroviral Therapy-Associated Tuberculosis and Mortality: A Pragmatic Randomized Controlled Trial. Open Forum Infect Dis. 2014 Mar;1(1):ofu038. PubMed PMID: 25734106; PubMed Central PMCID: PMC4324195.
8. Sagonda T, Mupfumi L, Manzou R, Makamure B, Tshabalala M, Gwanzura L, Mason P, Mutetwa R. Prevalence of Extensively Drug Resistant Tuberculosis among Archived Multidrug Resistant Tuberculosis Isolates in Zimbabwe. Tuberc Res Treat. 2014;2014:349141. PubMed PMID: 24967101; PubMed Central PMCID: PMC4054961.
Current profession
Current professional activities type:Research
