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Membership type: full

Stephanie Vargas Aguilar

Country of origin: Ecuador Currently in: United States, Dallas General field of specialization: Structural, Cell and Molecular Biology
Academic Background


2018 Doctorate Structural, Cell and Molecular Biology
2012 Undergraduate Medical and Health Sciences incl Neurosciences
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

I study the immune response to mouse neonatal heart regeneration

Publications resulting from Research: 

Vargas Aguilar, S, Cui, M, Tan, W, Sanchez-Ortiz, E, Bassel-Duby, R, Liu, N, and Olson, EN. The PD-1–PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration. Nat. Cardiovasc. Res. 2024 Mar; 10.1038/s44161-024-00447-7.

Gainullina, A, Sergushichev A, Artyomov MH, ImmGen Consortium. Resource Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes Cell Rep. 2023 Feb 28;42(2):112046. PMID: 36708514.

Subramanian S, Busch CJ, Molawi K, Geirsdottir L, Maurizio J, Vargas Aguilar S, Belahbib H, Gimenez G, Yuda RAA, Burkon M, Favret J, Gholamhosseinian Najjar S, de Laval B, Kandalla PK, Sarrazin S, Alexopoulou L, Sieweke MH. Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo. Nature Immunology. 2022 Mar;23(3):458-468. PMID: 35210623.

Vargas Aguilar S. (as part of the ImmGen Consortium) The Immunological Genome Project. ImmGen at 15. Nature Immunology. 2020 Jul;21(7):700-703. PMID: 32577013

Imperatore F, Maurizio J, Vargas Aguilar S, Busch CJ, Favret J, Kowenz-Leutz E, Cathou W, Gentek R, Perrin P, Leutz A, Berruyer C, Sieweke MH. SIRT1 regulates macrophage self-renewal. EMBO Journal. 2017 Aug 15;36(16):2353-2372. PMID: 28701484

Matcovitch-Natan O, Winter DR, Giladi A, Vargas Aguilar S, Spinrad A, Sarrazin S, Ben-Yehuda H, David E, Zelada González F, Perrin P, Keren-Shaul H, Gury M, Lara-Astaiso D, Thaiss CA, Cohen M, Bahar Halpern K, Baruch K, Deczkowska A, Lorenzo-Vivas E, Itzkovitz S, Elinav E, Sieweke MH, Schwartz M, Amit I. Microglia development follows a stepwise program to regulate brain homeostasis. Science. 2016 Aug 19;353(6301):aad8670. PMID: 27338705.

Dennemärker J, Lohmüller T, Müller S, Vargas Aguilar S, Tobin DJ, Peters C, Reinheckel T. Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biological Chemistry. 2010 Aug;391(8):913-22. PMID: 20536383.

Current profession

Current professional activities type: 
Postdoctoral Researcher at UT Southwestern Medical Center, Dallas, Texas, USA

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