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Membership type: friends

Deepak Balaji Thimiri Govindaraj

Country of origin: South Africa Currently in: South Africa, Pretoria General field of specialization: Biological Systems and Organisms
Academic Background

Degrees

2011 Doctorate Biological Systems and Organisms
Research and Profession

Current Research Activities

Biological Systems and Organisms


Publications resulting from Research: 


Publications in peer-reviewed Journal: (*equally contributed) (# Corresponding author) (No of Publications: 25 (First author: 14, Correspond/last author: 12 h- index: 8, Citation: 345 (Google Scholar))
1) http://europepmc.org/search?query=(AUTHORID%3A%220000-0002-9328-449X%22)
2) http://www.ncbi.nlm.nih.gov/pubmed/?term=Deepak+Balaji+OR+Thimiri+Govinda+Raj
3) https://www.scopus.com/authid/detail.uri?authorId=57195924317
2020 Crocker H, Gorda B, Pelosse M, Thimiri Govinda Raj DB, Berger I, SynBac: Enhanced Baculovirus Genomes By Iterative Recombineering. Methods in Molecular Biology in press.
2020 Subbiah L, Palanisamy S, Thimiri Govinda Raj DB#, Development and Characterization of Glucosamine sulfate magnetic nanoparticles for rheumatoid arthritis chemotherapy Micro-Nano Letters minor revision.
2020 Thimiri Govinda Raj DB#, Khan NA, Venkatachalam S., Arumugam S., Latha S., Efficient nanobio-technology method for magnetic lysosome enrichment using DMSA-SPMNP2.0 Bionanoscience 10, 529–33.
2020 Gnanasegaran N, Thimiri Govinda Raj DB, Arumugam S., Method for evaluating neuromodulatory properties of dental pulp stem cell as an in-vitro model for Parkinson’s disease. Methods in Molecular Biology 2020; 2125:193-196. 10.1007/7651_2019_261 .
2020 Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K, An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL. Leukemia 34(2):478-487.. https://rdcu.be/bPUoh (Key Publication).
2020 Thimiri Govinda Raj DB#, Khan NA, Venkatachalam S, Arumugam S, Palaniswamy S., Synthesis of hybrid gold nanoparticle (AuNP) functionalized superparamagnetic nanoparticles (SPMNP) for efficient coupling of biomolecules. Methods in Molecular Biology 2020; 2125: 73-75.
2020 Thimiri Govinda Raj DB#, Khan NA, Venkatachalam S, Arumugam S., BacMam System for Rapid Recombinant Protein Expression in Mammalian Cells. Methods in Molecular Biology 2020; 2125: 205-208.
2020 Thimiri Govinda Raj DB#, Khan NA, Venkatachalam S, Chu DT, Step by Step protocol for Superparamagnetic Nanoparticle based Plasma membrane isolation from eukaryotic cell. Methods in Molecular Biology. 2020; 2125: 173-179.
2020 Thimiri Govinda Raj DB#, Khan NA, Venkatachalam S, Chu DT, Arumugam S., Step by Step protocol for Superparamagnetic Nanoparticle based endosome and lysosome isolation from eukaryotic cell. Methods in Molecular Biology. 2020; 2125:167-172.
2019 Son TM, Ngoc VTN, Tran PT, Nguyen NP, Luong HM, Nguyen HT, Sharma K, Tu PV, Ha LS, Ha VN, Huy PV, Thimiri Govinda Raj DB, Chu DT., Prevalence of dental fear and its relationship with primary dental caries in 7-year-old-chidren. Pediatric Dental Journal doi: 10.1016/j.pdj.2019.04.002
2019 Chu DT, Nga VT, Nguyen KH, Tao Y, To TV, Ngoc VTN, Ba NV, Dao DTA, Hoan LN, Hung NP, Thu NTT, Pham V, Nghia LL, Vu LN, Pham TAV, Thimiri Govinda Raj DB., An update on anti-CD137 antibody in immunotherapies for cancer. Int J Mol Sci. 20(8). pii: E1822. doi: 10.3390/ijms20081822.
2019 Nhon BV, Long VH, Tung BV, Hao NSA, Hien TM, Khanh DN, Tuan NT, Show PL, Nga VT, Thimiri Govinda Raj DB, Chu DT., Prevalence and Risk factors of Hypertension in the Vietnamese Elderly High Blood Pressure & Cardiovascular Prevention . doi: 10.1007/s40292-019-00314-8
2019 Dinh, TC, Phuong TNT, Thuc VTM, Bac ND, Tien NV, Pham VH, Show PL, Tao Y, Ngoc VTN, Thi N, Ngoc B, Jurgoński A, Thimiri Govinda Raj DB, Tu PV, Ha VN, Czarzasta J, Chu DT. The effects of green tea on lipid metabolism and its potential applications for obesity and related metabolic disorders-An existing update. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13: 2, 1667-1673.
2019 Thimiri Govinda Raj DB#, Khan NA., Protocol for eukaryotic plasma membrane isolation using superparamagnetic nanoparticles. Journal of Magnetism and Magnetic Materials 476, 628-31.
2018 Thimiri Govinda Raj DB#, Prasanna SR, Venkatachalam S, Chu DT., Bioelectronic Medicine: Technology targeting future medicine European Biopharmaceutical Review 2018, pp. 70-71.
2018 Thimiri Govinda Raj DB#, Khan NA., Surface functionalization dependent subcellular localization of Superparamagnetic Nanoparticle in plasma membrane and endosome Nano convergence 5:4 29492374.
2018 Thimiri Govinda Raj DB#, Khan NA., Synthesis of hybrid Gold Nanoparticles functionalized Superparamagnetic Nanoparticles. Micro-Nano Letters 13 (3):292 10.1049/mnl.2017.0574.
2016 Thimiri Govinda Raj DB#, Khan NA., Designer Nanoparticle: Nano-biotechnology tool for Cell Biology, Nano Convergence 3 (1), 22. 28191432.
2016 Sari D, Gupta K, Thimiri Govinda Raj DB, Aubert A, Drnkova P, Garzoni F, Fitzgerald D, and Berger I., The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics Advances in Experimental Medicine and Biology 2016;896:199-215. 27165327.
2016 Khan NA, Willemarck N, Arnaud M, Binda MM, Dehairs J, Rueda-Rincon N, Talebi A, Bagadi M, Thimiri Govinda Raj DB, Vanderhoydonc F, Munck S, Chaltin P, Swinnen J. Identification of Drugs that Restore Primary Cilium Expression in Cancer Cells. OncoTarget 1; 7(9):9975-92. 26862738.
2014 Thimiri Govinda Raj DB, Vijayachandran LS, and Berger I., OmniBac: Universal Multigene Transfer Plasmids for Baculovirus Expression Vector Systems. Methods in Mol. biology 1091:123-30. 24203327.
2013 Vijayachandran LS*, Thimiri Govinda Raj DB*, Edelweiss E, Gupta K, Maier J, Gordeliy V, Fitzgerald DJ, Berger I.. Gene gymnastics: Synthetic biology for baculovirus expression vector system engineering. Bioengineered 4(5) 23328086 .
2011 Thimiri Govinda Raj DB, Ghesquiere B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, E.Waelkens, G.Borghs, Gevaert K, & Annaert W, A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Molecular Systems Biology (2011); 7:541. 22027552 . (Key Publication).
2010 Gupta SC, Mishra M, Sharma A, Deepak Balaji TG, Kumar R, Mishra RK, Chowdhuri DK. Chlorpyrifos induces apoptosis and DNA damage in Drosophila through generation of reactive oxygen species. Ecotoxicology & Environmental Safety (2010) 73:1415-23; 20627310.
2005 Deepak Balaji TG#, Suresh KD, Prasanna SR, Murugasen M Design of mixed microbial biosensor using T. cutaneum and K. marxianus culture for environmental monitoring. IJ Sci. & Tech. 1(3): 84–94. IJST80509
Publications in submission (#- Shared Corresponding Authorship)
2020 Crocker H, Gorda B, Pelosse M, Thimiri Govinda Raj DB# Berger I, # SynBac – A minimal Synthetic Baculovirus. https://research-information.bristol.ac.uk/files/155264825/BBI_launch_2018_booklet_0.8.pdf
2020 Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Schjesvold F, Tjønnfjord G, Munthe LA, and Tasken K., Drug Sensitivity Screening in CLL for Precision Cancer Therapy in submission.
2020 Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Tjønnfjord G, Schjesvold F, Munthe LA, and Tasken K., Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy.
2020 Latha S., Selvamani P., Thimiri Govinda Raj DB, Syed FTSS. Development and Characterization of Herbal Extract-loaded Superparamagnetic Nanovesicles for the Targeted Breast Cancer Therapy in submission.
2020 Latha S, Selvamani P, Thimiri Govinda Raj DB, Pal TK, Preparation and In-vitro Evaluation of Pantoprazole Sodium Magnetic Microspheres by Emulsion Solvent Evaporation Method
Publications in peer-reviewed conference proceedings:
2019 Skånland SS, Bendiksen H, Cremaschi A, Thimiri Govinda Raj DB, Munthe L, Tjønnfjord GE, Taskén K Exvivo Drug Sensitivity Screens Identify Personalized Treatment Options for CLL Patients. Blood 134: 1 5446. (Key Publication).
2019 Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K, An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL. Clinical Lymphoma, Myeloma & Leukemia 10.1016/j.clml.2019.07.201
2019 Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K, Ibrutinib plus venetoclax synergistically reduces signalling and viability in CLL: Implications for biomarker discovery: PB1870 Hemasphere 3:852 10.1097/01.HS9.0000565984.05497.e2.
2019 Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Schjesvold F, Tjønnfjord G, Munthe LA, and Tasken K., In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy. EHA meeting 2019 Hemasphere.
2019 Venkatachalam S, Baskaran S, Karthik R.S., Thimiri Govinda Raj DB, Ramesh Kumar T, Titanium diboride reinforced Aluminium composite as a robust material for automobile applications AIP Proceedings 2128, 020010; https://doi.org/10.1063/1.5117922
2018 Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Schjesvold F, Tjønnfjord G, Munthe LA, and Tasken K., In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy Blood 132 (1): 4676. (Key Publication).
2018 Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Tjønnfjord G, Schjesvold F, Munthe LA, Tasken K., Drug Sensitivity Screening on MM for Precision Cancer Therapy Blood 132 1: 4677.
2018 Thimiri Govinda Raj DB, Khan NA Surface functionalization dependent subcellular localization of Superparamagnetic Nanoparticle in plasma membrane and endosome. FEBS OpenBio 8 P.07-001-
2018 Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Wang D, Schjesvold F, Tjønnfjord GE, Munthe LA and Tasken K Drug Sensitivity screening in Chronic Lymphocytic Leukaemia (CLL) for precision cancer therapy. Hemasphere 2:S1: PB1854.
2018 Thimiri Govinda Raj DB, Gilberto M, Cremaschi A, Skånland SS, Gade A, Wang D, Tjønnfjord GE, Schjesvold F, Munthe LA and Tasken K Drug Sensitivity screening Multiple Myeloma (MM) for precision cancer therapy. Hemasphere 2:S1:PF550.
2017 Thimiri Govinda Raj DB#, Khan NA., Superparamagnetic Nanoparticle based subcellular fractionation for plasma membrane, endosome and lysosome isolation FEBS Journal 284, S1 102–3 10.1111/febs.14174.
2017 Thimiri Govinda Raj DB, Skånland SS, Wang D, Tjønnfjord GE, Munthe LA, Tasken K., Drug sensitivity screening in chronic lymphatic leukaemia and multiple myeloma for personalized cancer therapy. 22nd Congress of EHA Madrid, Spain, June 22–25, 2017 Haematologica 102: 882;
2016 Thimiri Govinda Raj DB#, Govinda Raj TS., Biological datasets to Pharmaceutical Drug Discovery: A Machine learning approach: New Horizons in Translational Medicine 3:1 30–61.
2014 Tharkeshwar AK, Gonnelli G, Trekker J, Staes A, Baatsen P, Thimiri Govinda Raj DB, Swinnen JV, Martens L, Lagae L, Gevaert K, Annaert W. Novel surface functionalized SPMNPs with engineered cellular uptake as a means for intracellular omics Molecular Biology of Cell 25(25):3987.
2014 Thimiri Govinda Raj DB, Garzoni F, Gavin AC, Gibson T and Berger I., SynBac: designer minimal baculovirus genome for drug discovery. FEBS Journal 281, (s1):9-55.
2012 Thimiri Govinda Raj DB, Ghesquiere B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, Strooper D B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W. A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes, FEBS Journal; 279; S1:P24
2008 Thimiri Govinda Raj DB#, Bartic C, Annaert W, Borghs G., Development & application of SPMNP for subcellular proteomics. https://lirias.kuleuven.be/handle/123456789/271280
Granted patent(s). https://register.epo.org/smartSearch?searchMode=smart&query=thimiri
2019 Thimiri Govinda Raj DB, Berger I., Improved baculoviral expression systems and methods of producing the same: EP14708951, US 61/ 762. 607 and WO2014122629
2015 Thimiri Govinda Raj DB, Lagae L, Annaert W, Borghs G, Plasma membrane isolation. (US Patent US8936935), US20150197742, EP2388589.
2013 Thimiri Govinda Raj DB, Annaert W, Borghs G Biarsenical NP for Invivo labeling, WO2013076159.
Peer-reviewed Book chapters: researchgate.net/profile/Deepak_Thimiri_Govinda_Raj
2020 Grobler L, Thimiri Govinda Raj DB#, Patents and technology transfer in CRISPR technology. In submission
2020 Thimiri Govinda Raj DB#, Nxumalo Z, Patents, Ethics, biosafety and regulation using CRISPR technology
2020 Ekene, Thimiri Govinda Raj DB#, Development of insect cell line using CRISPR technology in submission
2019 Nxumalo Z, Thimiri Govinda Raj DB#, Application and challenges of synthetic biology. Advances in Synthetic biology (Springer Nature Singapore). (Invited) Springer Nature 18, 307.
2019 Naidoo J*, Fok E*, Grobler L, Molaoa R, Nxumalo Z, Selvamani P, Latha S, Thimiri Govinda Raj DB#, Recent advances in genetic engineering tools for metabolic engineering. Engineering of Microbial Biosynthetic Pathways (Invited). Springer Nature Book Chapter In press.
2014 Thimiri Govinda Raj DB#, Ambigapathy K, Comparison of cell surface glycosylation on apoptotic cells Elsevier Nanobio Pharmaceutical Technology: Applications ISBN: 9789351072935.
2004 Deepak Balaji TG, Radhakrishnan PN, Krithikaa G, Sen RK, Biochemical approach in process development & optimization of biodiesel., 112-8; ISBN 81-7764-669-9.
Published Books
2011 Deepak Balaji TG# “Design of microbial biosensor” 978-3-8465-3576-9.
2011 Deepak Balaji TG#. Nanobiotechnology tool for cell surface omics analysis, LAP: 978-3845409221
2011 Deepak Balaji TG# Drosophila a model system for toxicity studies. LAP ISBN: 3845411473.
International Abstracts:
2019 Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Schjesvold F, Tjønnfjord GE, Munthe LA and Taskén K., Cancer Drug Sensitivity Screening and Precision Cancer Medicine for B-Cell Malignancies Proceedings of the Advances in Biomedical Research III., Mediteerian Institute of Life Sciences.
2017 Thimiri Govinda Raj DB#, Khan NA., Superparamagnetic Nanoparticle based subcellular fractionation for plasma membrane, endosome and lysosome isolation IBCM Conference Kalingrad, Russia Page 70.
2015 Thimiri Govinda Raj DB#, “Fluorescent Nano-switches for diagnostic application”.Protocol Exchange.
2015 Thimiri Govinda Raj DB, Garzoni F, Gavin AC, Gibson T, Berger I., SynBac: designer minimal baculovirus genome for drug discovery EMBO Enabling Technologies for Eukaryotic Synthetic Biology
2013 Thimiri Govinda Raj DB, Ghesquiere B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, Strooper DB, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, AnnaertW A novel strategy for comprehensive analysis of biomolecular composition of plasma membranes. EMBO YSF
2010 Ivanova EA, Sannerud R, Thimiri Govinda Raj DB, Esselens C, Dillen K, Munck S & Annaert W, “Presenilin1 and Presenilin2 are differentially distributed along the endocytic pathway” Biochemical Society Conference: Lysosomes in Health and Disease, London UK.
2010 Trekker J., Thimiri Govinda Raj D.B, Van Roy W., Dresselaers T., Lagae L Himmelreich U., “Effect of the core size of monodisperse SPMNPs on their relaxometric enhancing properties for MRI.” 8th Scientific and Clinical Applications of Magnetic Carriers, Rostock Germany; Talk 63
2010 Thimiri Govinda Raj DB#, Trekker J, Annaert W, Borghs B, Lagae L “Surface coating dependent selection of SPMNPs for whole cell isolation.” 8th Scientific & Clinical Applications of Magnetic Carriers, Rostock.
2008 Thimiri Govinda Raj DB#, Bartic C, Annaert W, Borghs G., Development & application of SPMNP for subcellular proteomics. NanoBiotech-Swiss Ch.
2007 Thimiri Govinda Raj DB#, Depalma R, Bartic C, Borghs G, Annaert W, Cellular uptake of SPMNPs as a strategy to isolate and characterize endosomal compartments", Frontiers Meeting BE.



Current profession

Current professional activities type: 
Industry

Prizes, Grants and Awards

Other Awards

Aug 2020
OWSD PhD Fellowship
OWSD PhD Fellowship- 2 Women Scientists to do PhD under my supervision.

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