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other-awards
Awards

July 2017 Research Grant (NRF-2017R1D1A3B03034382)

September 2012 Gold Medal “ Nepal Bidhya Bhusan”

August 2007 Doctoral dissertation Fellowship (KRF-2007-211-E00012)

December 2007 Outstanding Poster Award

September 2006 University Scholarship

Degrees:

2011
Doctorate     Medical and Health Sciences incl Neurosciences
Cancer Biology, Cancer Chemoresistance, Cancer Signaling, tumor vascularisation

Publications resulting from Research
1. Park Myo-Hyeon, Kim Ae Kyung, Manandhar Sarala, Oh Su-Young, Jang Gun-Hyuk, Li Kang, Hyeon Do Young, Lee Sun-Hee, Yoon Soo-Hyun, Lee Hye Eun, Lee SeHyung, Hwang Daehee, Byun Kyunghee and Lee You Mie. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. Elife. 2019 Aug 20;8. pii: e46012. doi: 10.7554/eLife.46012.
2. Manandhar Sarala and Lee You Mie. Emerging role of RUNX3 in the regulation of tumor Microenvironment. BMB Rep. 2018, 51(4): 174–181.
3. Manandhar Sarala, Kim Chang-gu, Lee Sun-Hee, Kang Soo Hyun, Basnet Nikita, and Lee You Mie. Exostosin 1 regulates cancer cell stemness in doxorubicin resistant breast cancer cells. Oncotarget. 2017, 3: 8(41):70521-7053. 4. Lee Sun Hee, Manandhar Sarala, and Lee You Mie. Role of RUNX in hypoxiainduced responses and angiogenesis. In: Ito, Y eds. Diverse Roles of RUNX Proteins in Development and Cancer. Adv Exp Med Biol. 2017: 962:449-469.(Equal contribution)
5. Manandhar Sarala, Choi Bo-hyun, Jung Kyeong-Ah, Ryoo In-geun, Song Mingu, Kang Su Jin, Choi Han-Gon, Kim Jung-Ae, Park Pil-Hoon and Kwak Mi- Kyoung. NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity. Free Radic Biol Med. 2012, 52(9):1773-1785.
6. Manandhar Sarala, Lee Sangwhan, and Kwak Mi-Kyoung. Effect of Stable Inhibition of NRF2 on Doxorubicin Sensitivity in Human Ovarian Carcinoma OV90 Cells, Arch Pharm Res. 2010, 33(5):717-726. (Selected by Editors)
7. Shim Gi-seong, Manandhar Sarala, Shin Dong-ha, Kim Tae-Hyoung, Kwak MiKyoung. Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway. Free Radic Biol Med. 2009, 47 (11):1619–1631. (Equal contribution)
8. Manandhar Sarala, You Aram, Lee Eung-Seok, Kim Jung-Ae, Kwak Mi- Kyoung, Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 activator, Journal of Pharmacy and Pharmacology, 2008, 60(7): 879-887.
9. Cho Jeong-Min, Manandhar Sarala, Lee Hyang Rim, Park Hyun Min, Kwak Mi- Kyoung. Role of the Nrf2 antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to Cancer cell resistance; Cancer Lett. 2008, 260 (1-2): 96-108.
10. Manandhar Sarala, Cho Jeong-Min, Kim Jung- Ae, Kensler Thomas W, Kwak Mi- Kyoung. Induction of Nrf2- regulated genes by 3H-1,2- dithiole 3-thione through the ERK signaling pathway in Murine Keratinocyte, European Journal of Pharmacology. 2007, 577 (1-3): 17-27.

7 Lakes Proteoglycans conference
2025
icon-pin-location Italy
American Association of Cancer Research (AACR)
2025
icon-pin-location San Diego, USA
Matrix Biology Symposium
2025
icon-pin-location KAIST, South Korea
American Association of Cancer Research (AACR)
2025
icon-pin-location San diego, USA

3rd International Conference on Bioscience and Biotechnology
2025
icon-pin-location Pokhara, Nepal
The Pharmaceutical Society of Korea
2025
icon-pin-location The-K Hotel, Seoul, South Korea
Japan-Korea Joint Symposium of Vascular Biology
2025
icon-pin-location Muju, South Korea